M. Hirata

Publications69
h-index14
Citations675
Highly Influential Citations6
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Specific role of an α,β-unsaturated carbonyl group in γ-glutamylcysteine synthetase induction by prostaglandin A2
Effects of glutathione depletion on the acute nephrotoxic potential of arsenite and on arsenic metabolism in hamsters.
New substrate for determination of serum lecithin:cholesterol acyltransferase.
TLDR
Results suggest that the enzymatically measuring the decrease in unesterified cholesterol after incubation of serum with liposomes is sensitive, reproducible, and not greatly influenced by serum components.
Improvement of some pharmaceutical properties of DY-9760e by sulfobutyl ether beta-cyclodextrin.
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes.
TLDR
E 5110 was found to be nearly as effective as phenytoin, but less potent than rifampicin, on the basis of 6 beta-OH-T induction.
Specific role of an alpha,beta-unsaturated carbonyl group in gamma-glutamylcysteine synthetase induction by prostaglandin A2.
TLDR
It is suggested that an alpha,beta-unsaturated carbonyl moiety is responsible for enhancing the biosynthesis of gamma-glutamylcysteine synthetase in cultured cells.
Glucuronidation and sulfation of p-nitrophenol in isolated rat hepatocyte subpopulations. Effects of phenobarbital and 3-methylcholanthrene pretreatment.
Studies of isoniazid metabolism in isolated rat hepatocytes by mass fragmentography.
Effects of phenobarbital and 3-methylcholanthrene pretreatments on monooxygenase activities and proportions of isolated rat hepatocyte subpopulations.
Metabolism of isoniazid and free hydrazine formation in isolated rat hepatocytes.
TLDR
Analysis of kinetic parameters of metabolic pathways and enzymological study of rat liver homogenate revealed that hydrazine was formed preferentially from INH, catalyzed by soluble hydrolytic enzymes.
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