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Characterization of Respiratory Drug Delivery with Enhanced Condensational Growth using an Individual Path Model of the Entire Tracheobronchial Airways
- G. Tian, P. Longest, Guoguang Su, M. Hindle
- Environmental ScienceAnnals of Biomedical Engineering
- 1 March 2011
Evaluating the delivery of inhaled pharmaceutical aerosols using an enhanced condensational growth (ECG) approach in an airway model extending from the oral cavity to the end of the tracheobronchial (TB) region indicated that targeting the region of TB deposition by controlling the inlet temperature conditions and initial aerosol size also appeared possible.
Comparing MDI and DPI Aerosol Deposition Using In Vitro Experiments and a New Stochastic Individual Path (SIP) Model of the Conducting Airways
The developed in silico model provides new insights into the lung delivery of pharmaceutical aerosols and can be applied in future studies in combination with pharmacokinetic analysis to establish bioequivalence between devices.
Evaluation of the Respimat Soft Mist Inhaler using a concurrent CFD and in vitro approach.
Results of this study indicate that modifications to the current Respimat MP and control of specific patient variables may significantly reduce deposition in the device and may decrease high oropharyngeal drug loss observed in vivo.
Aerosolization characteristics of dry powder inhaler formulations for the excipient enhanced growth (EEG) application: effect of spray drying process conditions on aerosol performance.
Numerical Model to Characterize the Size Increase of Combination Drug and Hygroscopic Excipient Nanoparticle Aerosols
A validated mathematical model of aerosol size increase for hygroscopic excipients and combination excipient–drug particles is developed and applied to characterize growth under typical respiratory conditions and showed that the droplet size increase could be effectively correlated with the product of a newly defined hygroScopic parameter and initial volume fractions of the drug and excipient in the particle.
Evaluation and modification of commercial dry powder inhalers for the aerosolization of a submicrometer excipient enhanced growth (EEG) formulation.
Validating CFD Predictions of Pharmaceutical Aerosol Deposition with In Vivo Data
CFD simulations with the SIP modeling approach were shown to accurately predict regional deposition throughout the lungs for multiple aerosol types and different in vivo assessment methods.
Development of a stochastic individual path (SIP) model for predicting the tracheobronchial deposition of pharmaceutical aerosols: Effects of transient inhalation and sampling the airways
Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in a Mouth-Throat and Upper Tracheobronchial Model
The ECG platform appears to offer an effective method of delivering nano-aerosols through the extrathoracic region, with minimal deposition, to the tracheobronchial airways and beyond.
Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth
- P. Longest, J. McLeskey, M. Hindle
- Environmental ScienceAerosol science and technology : the journal of…
- 28 April 2010
A respiratory drug delivery approach is suggested in which nanoaerosols in the size range of 500 nm are delivered in conjunction with a saturated or supersaturated air stream, to ensure minimal deposition and loss in the mouth-throat region while condensational growth in the respiratory tract can be used to ensure maximal lung retention.