Mechanisms of stress in the brain
The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic…
Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic-Pituitary-Adrenal Axis
Findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB1 receptor signaling contributes to the magnitude of the HPA response.
Neurobiological Interactions Between Stress and the Endocannabinoid System
Data presented create a compelling argument that eCB signaling is an important regulatory system in the brain that largely functions to buffer against many of the effects of stress and that dynamic changes in this system contribute to different aspects of the stress response.
Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
The data suggest that the endocannabinoid system in cortical and subcortical structures is differentially altered in an animal model of depression and that the effects of CUS on CB1 receptor binding site density are attenuated by antidepressant treatment while those on endOCannabinoid content are not.
Downregulation of Endocannabinoid Signaling in the Hippocampus Following Chronic Unpredictable Stress
The data suggest that stress-induced downregulation of hippocampal eCB signaling contributes to problems in behavioral flexibility and could play a role in the development of perseveratory and ruminatory behaviors in stress-related neuropsychiatric disorders.
Endogenous cannabinoid signaling is essential for stress adaptation
An important role for endocannabinoid signaling is demonstrated in the process of stress HPA habituation, and it is suggested that AEA and 2-AG modulate different components of the adrenocortical response to repeated stressor exposure.
Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling.
The hypothesis that glucocorticoid-induced fast feedback inhibition of the HPA axis is mediated by a nongenomic signaling mechanism that involves endocannabinoid signaling at the level of the PVN is supported.
Functional Interactions between Stress and the Endocannabinoid System: From Synaptic Signaling to Behavioral Output
- M. Hill, Sachin Patel, P. Campolongo, J. Tasker, C. Wotjak, J. Bains
- Biology, PsychologyJournal of Neuroscience
- 10 November 2010
The evidence reviewed here demonstrates that endocannabinoid signaling is involved in both activating and terminating the hypothalamic-pituitary-adrenal axis response to both acute and repeated stress.
Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report.
- M. Hill, G. Miller, W. V. Ho, B. Gorzalka, C. Hillard
- Medicine, PsychologyPharmacopsychiatry
- 1 March 2008
These are the first clinical data to indicate that the endocannabinoid system may be disturbed in affective disease, and suggest that future research is required to determine the relevance of these changes with respect to disease manifestation and pharmacotherapy.
Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response
The ability of stress-induced glucocorticoid signaling within mPFC to terminate HPA axis activity is mediated by a local recruitment of endocannabinoid signaling, which supports a model in which endoc cannabinoidoid receptor engagement to activation of corticolimbic relays that inhibit corticosterone secretion.