• Publications
  • Influence
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.
TLDR
The results of this study suggest that the CYP2C9*2 and CYP1c9*3 polymorphisms are associated with an increased risk of overanticoagulation and of bleeding events among patients in a warfarin anticoagulated clinic setting, although small numbers in some cases would suggest the need for caution in interpretation.
Assessing the cost-effectiveness of pharmacogenomics
TLDR
It is found that pharmacogenomics offers great potential to improve patients' health in a cost-effective manner, and careful evaluations are needed on a case-by-case basis before investing resources in research and development of pharmacogenomic-based therapeutics and making reimbursement decisions.
The quality of life impact of acute exacerbations of chronic bronchitis (AECB): A literature review
TLDR
Longitudinal studies, assessing pharmacological and non-pharmacological interventions, found that HRQL improved from exacerbation to recovery, with responsiveness depending on sensitivity of the measure.
The cost-effectiveness of interleukin-1 genetic testing for periodontal disease.
TLDR
The model demonstrates that three clinical parameters are highly influential in determining if IL-1 testing can be implemented in a primary care setting in a cost-effective manner, and shows a wide range of outcomes reflecting the incomplete understanding of the biology, optimal treatment, and genetic susceptibility of periodontal diseases.
Health Economic Evaluation of Non-Melanoma Skin Cancer and Actinic Keratosis
TLDR
The analysis suggests that additional data on treatment practice patterns and epidemiology need to be collected, and incorporated with efficacy and safety data in a formal decision-analytic framework to assist decision makers in allocating scarce healthcare resources.
Optimizing CAD diagnosis in China with CT angiography.
The economic impact of acute exacerbations of chronic bronchitis in the United States and Canada: a literature review.
TLDR
To evaluate literature on the economic impact of AECB in terms of cost of illness, cost of treatments, and cost-effectiveness, further research is needed to guide clinical decision making and the conduct of disease management programs.
Managed care in the genomics era: assessing the cost effectiveness of genetic tests.
TLDR
Criteria for a robust cost-effectiveness analysis of genetic tests should be used to inform the decision-making process in the context of ethical, legal, and social issues related to genetic testing.
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