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Enalapril maleate and a lysine analogue (MK-521): disposition in man.
Serum concentration v time profiles for both drugs were polyphasic and exhibited prolonged terminal phases, indicating lack of significant metabolism of these agents, apart from the bioactivation of enalapril. Expand
Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system.
A close correlation between percent inhibition of plasma converting enzyme activity and the serum concentration of active metabolite was observed, and converting enzyme blockade as expressed by the ratio plasma angiotensin II/angiotens in I was closely correlated with serum active metabolites levels. Expand
Effects of enalapril, a new converting enzyme inhibitor, in hypertension
The new angiotensin converting enzyme inhibitor enalapril maleate was given in single oral doses of 2.5, 5, and 10 mg to 11 hospitalized patients with uncomplicated essential hypertension who were onExpand
PGF2α-induced loss of corpus luteum gonadotrophin receptors
To determine if this action of PGF 2α may occur as a consequence of an induced loss of gonadotrophin receptors, binding of hCG to rat luteal tissue was measured following P GF 2α treatment in vivo. Expand
Para-O-Methylation of Dopamine in Schizophrenic and Normal Individuals
No evidence could be found for the presence of para-O-methyl derivatives of epinephrine, norepinephrine, or dopamine, and the relative rates of formation of the two isomeric monomethyl compounds in vitro did not change with time during the course of the reaction, and were the same whether crude or a purified COMT preparation was used. Expand
Pharmacokinetics of repeated single oral doses of enalapril maleate (MK-421) in normal volunteers.
Observed fluctuations in serum and urine data during apparent steady state suggest some day-to-day variability in the absorption of enalapril maleate and/or its hydrolysis to enAlaprilat. Expand
Biological Activities of a New Steroidal Inhibitor of δ4-5α-Reductase
4-MA proved to be a relatively nontoxic compound which showed little or no antifertility activity in either male or female rats, no significant estrogenic, progestational, androgenic, or gonadotropin-inhibiting potency, and it did not affect serum prolactin levels. Expand
The antiparkinsonian actions and pharmacokinetics of transdermal (+)‐4‐Propyl‐9‐hydroxynaphthoxazine (+ PHNO): Preliminary results
(+)‐4‐Propyl‐9‐hydroxynaphthoxazine (+ PHNO) is a potent dopamine agonist that has been administered transdermally to four patients with Parkinson's disease and “on‐off” fluctuations and the effect was measured as an increased duration of action of individual levodopa doses. Expand
Renal handling of alendronate in rats. An uncharacterized renal transport system.
The renal handling of alendronate in rats by standard clearance procedures with inulin as a marker of glomerular filtration rate is characterized, and the renal excretion is drastically reduced in rats with acute renal failure. Expand
Pharmacokinetics of lisinopril (IV/PO) in healthy volunteers.
The half-life for the terminal phase was not predictive of steady-state parameters when ten daily doses of lisinopril were administered orally to healthy volunteers, and the observations in these studies are similar to those reported for enalaprilat, the active metabolite of the ACE inhibitor, en alapril maleate. Expand