• Publications
  • Influence
Transbronchial Cryobiopsy: A New Tool for Lung Biopsies
Background: Specimens from transbronchial lung biopsies lack sufficient quality due to crush artifact and are generally too small for diagnosis of diffuse lung diseases. Flexible cryoprobes have beenExpand
  • 234
  • 11
  • Open Access
Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG.
UNLABELLED Recently, the thymidine analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) was suggested for imaging tumoral proliferation. In this prospective study, we examined whether (18)F-FLT betterExpand
  • 395
  • 7
Randomized phase III study of surgery alone or surgery plus preoperative cisplatin and gemcitabine in stages IB to IIIA non-small-cell lung cancer.
PURPOSE This study aimed to determine whether three preoperative cycles of gemcitabine plus cisplatin followed by radical surgery provides a reduction in the risk of progression compared with surgeryExpand
  • 113
  • 7
Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer.
UNLABELLED Previous studies have shown that vertebral bone metastases (BM) not seen on planar bone scintigraphy (BS) might be present on (18)F-fluoride PET scans or at MRI. Therefore, we evaluatedExpand
  • 258
  • 6
  • Open Access
Inhibition of MMP-9 expression by PPARγ activators in human bronchial epithelial cells
Background: The release of matrix degrading enzymes such as matrix metalloproteinase 9 (MMP-9) from bronchial epithelial cells is critically involved in airway wall remodelling in chronicExpand
  • 61
  • 6
  • Open Access
Different Effects of Growth Factors on Proliferation and Matrix Production of Normal and Fibrotic Human Lung Fibroblasts
Objectives and methods: In idiopathic pulmonary fibrosis (IPF), proliferation of fibroblasts and increased matrix deposition result in pulmonary damage and respiratory insufficiency. We culturedExpand
  • 162
  • 5
Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial
Forceps, brushes or needles are currently the standard tools used during flexible bronchoscopy when diagnosing endobronchial malignancies. The new biopsy technique of cryobiopsy appears to provideExpand
  • 148
  • 4
Assessment of COPD severity by computed tomography: correlation with lung functional testing.
CT scans of 474 patients with suspected chronic obstructive pulmonary disease (COPD) were retrospectively evaluated by automated software. There was a correlation between the total lung capacityExpand
  • 29
  • 4
F‐18 NaF PET for Detection of Bone Metastases in Lung Cancer: Accuracy, Cost‐Effectiveness, and Impact on Patient Management
As bone metastases might be present in lung cancer despite a normal bone scan, we examined various alternatives prospectively. Positron emission tomography using F‐18 sodium fluoride (PET) and singleExpand
  • 162
  • 2
Cryorecanalization: a new approach for the immediate management of acute airway obstruction.
OBJECTIVES Endobronchial cryotherapy is an established recanalization method for stenoses of the respiratory tract. However, previous applications of cryotherapy have not been immediately effective,Expand
  • 91
  • 2
  • Open Access