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Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury.
  • M. Hess, N. Manson
  • Biology
    Journal of molecular and cellular cardiology
  • 1 November 1984
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The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection.
TLDR
This thesis highlights several novel therapeutic strategies aimed at interrupting the oxygen free radical mediated component of ischaemia/reperfusion injury and points out and emphasises the growing importance of the role of singlet oxygen.
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PGH Synthase and Lipoxygenase Generate Superoxide in the Presence of NADH or NADPH
TLDR
It is concluded that PGH synthase and lipoxygenase produce superoxide via a side-chain reaction dependent on the presence of suitable reducing cosubstrate, analogous to that described for peroxidases in general.
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Dynamic exercise normalizes resting blood pressure in mildly hypertensive premenopausal women.
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Early and late forms of cyclosporine nephrotoxicity: studies in cardiac transplant recipients.
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Psychosocial factors, quality of life, and psychological distress: ethnic differences in patients with heart failure.
TLDR
The importance of considering the unique psychosocial needs of diverse populations to appropriately target clinical interventions in heart failure patients is suggested.
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Appearance of Superoxide Anion Radical in Cerebral Extracellular Space during Increased Prostaglandin Synthesis in Cats
TLDR
Results show that most of the nitroblue terrazolium reduction was accounted for by superoxide anion radical generated in the course of arachidonate metabolism via the cyclooxygenase pathway, and the most likely explanation for these findings is that increased metabolism of exogenous or endogenous archidonate via cyclo oxygengenase results in the appearance of superoxideAnion radical in cerebral extracellular space.
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Involvement of free radicals in the pathophysiology of ischemic heart disease.
TLDR
It is established that the intracellular pH of the ischemic myocardium is in the range of 6.4 but the role of protons and potential role of free radicals have not been identified but it is hypothesized that proton and free radicals may interact to produce the excitation–contraction uncoupling of theIschemic Myocardium.
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Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice.
TLDR
An obligatory role for iNOS in mediating the cardioprotective effect induced by MLA was confirmed with the pharmacological inhibition and gene knockout mice, demonstrating a direct association of infarct size reduction with increased NO production with MLA350.
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Oxidant stress increases heat shock protein 70 mRNA in isolated perfused rat heart.
TLDR
It is demonstrated that oxidant stress directly increases HSP 70 mRNA in the rat heart through schemia/reperfusion and preconditioning of the heart by coronary artery occlusions.
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