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Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care
TLDR
Prevalence rates of different physical illnesses as well as important individual lifestyle choices, side effects of psychotropic treatment and disparities in health care access, utilization and provision that contribute to these poor physical health outcomes are reported. Expand
Genome-wide association study identifies five new schizophrenia loci
TLDR
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. Expand
The five-factor model of the Positive and Negative Syndrome Scale II: A ten-fold cross-validation of a revised model
TLDR
The five-factor model developed in this study is an improvement above previously published models as it represents a complex factor model and is more stable. Expand
Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
TLDR
The metabolic and cardiovascular risks of various antipsychotic medications in adults and children are outlined, the disparities in health care are defined, and recommendations for screening and monitoring of patients taking these agents are made. Expand
Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level
TLDR
The adoption of the recommendations presented in this paper across health care systems throughout the world will contribute to a significant improvement in the medical and related psychiatric health outcomes of patients with SMI. Expand
Personal stigma in schizophrenia spectrum disorders: a systematic review of prevalence rates, correlates, impact and interventions
TLDR
While socio‐demographic variables were only marginally associated with stigma, psychosocial variables, especially lower quality of life, showed overall significant correlations, and illness‐related factors showed heterogeneous associations, except for social anxiety that was unequivocally associated with personal stigma. Expand
Metabolic syndrome in people with schizophrenia: a review
TLDR
The psychiatrist needs to be aware of the potential metabolic side effects of antipsychotic medication and to include them in the risk/benefit assessment when choosing a specific antipsychotics. Expand
Typical and atypical antipsychotics differentially affect long-term incidence rates of the metabolic syndrome in first-episode patients with schizophrenia: A retrospective chart review
TLDR
Rates of MetS at the first episode of schizophrenia today are not different from those of patients 15 to 20 years ago, counters the notion that the high rates of metabolic abnormalities in patients with schizophrenia currently reported are mainly due to lifestyle changes over time in the general population. Expand
Cardiovascular disease and diabetes in people with severe mental illness.
TLDR
The intention is to initiate co-operation and shared care between the different health care professionals and to increase the awareness of psychiatrists caring for patients suffering from severe mental illness to screen and treat increased cardiovascular risk factors and diabetes. Expand
The five-factor model of the Positive and Negative Syndrome Scale I: Confirmatory factor analysis fails to confirm 25 published five-factor solutions
TLDR
Despite variability in age, sex, duration of illness, admission status, etc., in the different subsamples, the structure of symptoms is the same for all patients with schizophrenia, testing the goodness-of-fit of all previously published five-factor models of the Positive and Negative Syndrome Scale indicates. Expand
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