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Entorhinal cortex of the rat: Cytoarchitectonic subdivisions and the origin and distribution of cortical efferents
The origins and terminations of entorhinal cortical projections in the rat were analyzed in detail with retrograde and anterograde tracing techniques. Retrograde fluorescent tracers were injected inExpand
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Subthalamotomy in parkinsonian monkeys. Behavioural and biochemical analysis.
Nineteen Macaca fascicularis monkeys were divided into four different groups: Group A (n = 3), control; Group B (n = 3), monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP);Expand
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  • Open Access
Consequences of Nigrostriatal Denervation on the Functioning of the Basal Ganglia in Human and Nonhuman Primates: An In Situ Hybridization Study of Cytochrome Oxidase Subunit I mRNA
To examine the consequences of nigrostriatal denervation and chronic levodopa (l-DOPA) treatment on functional activity of the basal ganglia, we analyzed, using in situhybridization, the cellularExpand
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  • Open Access
Distribution of galanin-like immunoreactivity in the human brain
The distribution of galanin-like immunoreactivity has been studied in complete coronal sections taken from 9 normal human brains (4 male, 5 female mean age 54, range 42-72 years).Expand
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Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset
Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days,Expand
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Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism
Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non–cell-autonomous mechanisms, particularly chronic inflammation mountedExpand
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The subthalamic nucleus: A possible target for stereotaxic surgery in parkinson's disease
Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's diseaseExpand
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No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. ToExpand
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MPTP-induced parkinsonism in primates: pattern of striatal dopamine loss following acute and chronic administration
We analyzed the effect of two different schedules of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment on dopaminergic systems in the striatum of cynomolgus monkeys. Acute MPTP treatmentExpand
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Cortically projecting cells in the periaqueductal gray matter of the rat. A retrograde fluorescent tracer study
The topographical organization of the afferent input from the periaqueductal gray matter (PAG) to the cerebral cortex has been assessed in rats by retrograde transport of the fluorescent tracers FastExpand
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