SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma.
- J. Bayley, H. Kunst, M. Robledo
- Medicine, BiologyThe Lancet Oncology
- 1 April 2010
Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances
- J. Llorente, F. López, C. Suárez, M. Hermsen
- MedicineNature Reviews Clinical Oncology
- 1 August 2014
Genetic profiling and the development of in vitro cell lines and animal models currently form the basis for future targeted anticancer therapies, and advances in imaging techniques, endoscopic surgical approaches, and radiotherapy are reviewed.
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
- M. Hermsen, C. Postma, G. Meijer
- 1 October 2002
Evidence was found that these chromosomal abnormalities occurred in specific combinations of a few abnormalities rather than as a mere accumulation of events, indicating the existence of multiple independent chromosomal instability pathways of colorectal cancer progression.
Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out.
- H. Neumann, Z. Erlic, C. Eng
- Medicine, BiologyCancer Research
- 15 April 2009
Evidence is given that clinical parameters can predict for mutation and help prioritize gene testing to reduce costs in HNP, and such strategy is cost-saving in the practice of genetics-based personalized health care.
High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma.
- A. Udager, D. Rolland, N. Brown
- Medicine, BiologyCancer Research
- 1 July 2015
Identical EGFR genotypes were found in matched pairs of ISP and associated SNSCC, providing the first genetic evidence of a biologic link between these tumors, and rationalize consideration of irreversible EGFR inhibitors in the therapy of these tumors.
Amplicon Mapping and Expression Profiling Identify the Fas-Associated Death Domain Gene as a New Driver in the 11q13.3 Amplicon in Laryngeal/Pharyngeal Cancer
- J. Gibcus, L. Menkema, E. Schuuring
- MedicineClinical Cancer Research
- 1 November 2007
It is hypothesized that FADD is a marker to select patients that might benefit from Taxol-based chemoradiotherapy because of the frequent amplification of the 11q13 region and concomitant overexpression of FADD in head and neck squamous cell carcinomas.
Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line.
- R. Steenbergen, M. Hermsen, P. Snijders
- BiologyCancer Research
- 15 November 1995
Data support a role for HPV 16 in the development of a subset of oral cancers, presumably in concert with loss of function of tumor suppressor genes at 11q and 18q.
Genetic analysis of 53 lymph node‐negative breast carcinomas by CGH and relation to clinical, pathological, morphometric, and DNA cytometric prognostic factors
- M. Hermsen, J. Baak, P. V. van Diest
- MedicineJournal of Pathology
- 1 December 1998
The results of CGH analysis of 53 lymph node‐negative breast carcinomas are presented and correlated with a set of clinico‐pathological and cytometric features with strong prognostic value, including gains at 8q, 11q13, 17q, and 20q, which may be of potential prognosticvalue.
High-resolution mapping identifies a commonly amplified 11q13.3 region containing multiple genes flanked by segmental duplications
- J. Gibcus, K. Kok, E. Schuuring
- BiologyHuman Genetics
- 1 April 2007
It is hypothesized that the selection for genes through amplification of the 11q13.3 region is determined by the ability to form DNA breaks within specific regions and, consequently, results in large amplicons containing multiple genes.