M. Herkenham

Publications161
h-index80
Citations27,862
Highly Influential Citations1,178
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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
TLDR
It is considered premature to rename cannabinoid receptors after an endogenous agonist as is recommended by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification, because pharmacological evidence for the existence of additional types of cannabinoid receptor is emerging and other kinds of supporting evidence are still lacking. Expand
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
TLDR
The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement. Expand
Cannabinoid receptor localization in brain.
TLDR
The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience. Expand
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
TLDR
Most, but not all, CNS effects of Delta9-THC are mediated by the CB1 receptor, which accounts for the abuse potential of cannabis, while other effects such as analgesia suggest potential medicinal applications. Expand
Efferent connections of the habenular nuclei in the rat
The efferent connections of the medial (MHb) and lateral (LHb) habenular nuclei in the rat were demonstrated autoradiographically following small injections of tritiated amino acids localized within… Expand
Afferent connections of the habenular nuclei in the rat. A horseradish peroxidase study, with a note on the fiber‐of‐passage problem
The afferent connections of the habenular complex in the rat were examined by injecting horseradish peroxidase (HRP) into discrete portions of the habenular nuclei by microelectrophoresis.
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
TLDR
Autoradiography data show that cannabinoid receptors in the basal ganglia are neuronally located on striatal projection neurons, including their axons and terminals. Expand
The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems
Mesostriatal projections, which arise from dopaminergic and non- dopaminergic neurons in the ventral tegmental area, substantia nigra, and retrorubral area, are compartmentally organized in the… Expand
Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats.
TLDR
The discrete changes in NPY, POMC, GAL and CRH gene expression in food-restricted and food-deprived animals suggest the involvement of these peptides in abnormal appetitive behavior and weight loss associated with human eating disorders. Expand
The connections of the nucleus reuniens thalami: Evidence for a direct thalamo‐hippocampal pathway in the rat
  • M. Herkenham
  • Biology, Medicine
  • The Journal of comparative neurology
  • 15 February 1978
TLDR
The afferent and efferent connections of the rat's midline nucleus reunions thalami (reuniens) were studied by experiments using the methods of retrograde cell marking by horseradish peroxidase and anterograde fiber tracing by autoradiography to provide the first evidence of a direct thalamo‐hippocampal connection. Expand
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