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Quantification of biofilm structures by the novel computer program COMSTAT.
TLDR
Analysis of biofilms of P. aureofaciens growing on 0.03 mM, 0.1 mM or 0.5 mM citrate minimal media showed that mean biofilm thickness increased with increasing citrate concentration, whereas surface to volume ratio increased with higher citrate concentrations. Expand
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
TLDR
A synthetic derivate of natural furanone compounds can act as a potent antagonist of bacterial quorum sensing and inhibited virulence factor expression in a mouse pulmonary infection model. Expand
Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector
TLDR
GeneChip-based transcriptome analysis revealed that garlic extract and 4-NPO had specificity for QS-controlled virulence genes in Pseudomonas aeruginosa, and these two QSIs significantly reduced P. aerug inosa biofilm tolerance to tobramycin treatment as well as virulence in a Caenorhabditis elegans pathogenesis model. Expand
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.
TLDR
It is demonstrated that the furanone compound specifically represses expression of a PlasB-gfp reporter fusion without affecting growth or protein synthesis, indicating a general effect on target genes of the las quorum sensing circuit. Expand
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.
TLDR
The known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants are discussed. Expand
gfp-Based N-Acyl Homoserine-Lactone Sensor Systems for Detection of Bacterial Communication
TLDR
This green fluorescent AHL sensor provides a state-of-the-art tool for studies of communication between the individuals present in mixed bacterial communities and allows for real-time measurements of fluctuations in AHL concentrations. Expand
N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms.
TLDR
Novel Gfp-based biosensors for non-destructive, in situ detection of AHLs and measurements of extracellular proteolytic activities of defined quorum-sensing mutants grown in media complemented with AHL extracts prepared from culture supernatants of various wild-type and mutant strains supported the view of unidirectional signalling between the two strains. Expand
The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility.
TLDR
The isolation of random mini-Tn5 insertion mutants of B. cepacia H111 defective in biofilm formation on an abiotic surface is reported and it is demonstrated that one of these mutants no longer produces N-acylhomoserine lactones (AHLs) due to an inactivation of the cepR gene. Expand
Alginate Overproduction Affects Pseudomonas aeruginosa Biofilm Structure and Function
TLDR
It is reported that the overproduction of alginate affects biofilm development on an abiotic surface and suggests that an important consequence of the conversion to mucoidy is an altered biofilm architecture that shows increasing resistance to antimicrobial treatments. Expand
Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
TLDR
Based on a lower intrinsic activity at D2 receptors and higher binding affinities for 5-HT1A/2A receptors than aripiprazole, brexpiprazoles would have a favorable antipsychotic potential without D2 receptor agonist- and antagonist-related adverse effects. Expand
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