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The Role of CD44 in Disease Pathophysiology and Targeted Treatment
TLDR
This review focuses both CD44-hyaluronan dependent and independent CD44 signaling and the role of CD44–HA interaction in various pathophysiologies and the recent advances in novel treatment strategies that exploit the CD44 –HA interaction either for direct targeting or for drug delivery. Expand
Molecular Characterization of Renal Cell Carcinoma: A Potential Three-MicroRNA Prognostic Signature
TLDR
The interconnected discovery–validation approach identified a three-miRNA signature as a potential predictor of disease outcome in RCC patients as well as potentially at an early stage detect and predict metastasis. Expand
Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer
TLDR
It is delineates that sHA-F targets tumor-associated HA-HAase system and could be potentially useful in BCa treatment and inhibited tumor growth in 253J-L and HT1376 xenograft models. Expand
β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer
TLDR
This work shows for the first time that β-arrestins have prognostic significance for predicting metastasis and response to chemotherapy in bladder cancer and ARRBs regulate cancer stem cell-like properties in bladder cancers and are potential prognostic indicators for tumor progression and chemotherapy response. Expand
A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Patients with Bladder Cancer
TLDR
This study discovered the first naturally-occurring eukaryotic/human Chase and connected it to disease pathology, specifically cancer. Expand
HYAL4-V1/Chondroitinase (Chase) Drives Gemcitabine Resistance and Predicts Chemotherapy Failure in Patients with Bladder Cancer
TLDR
This study investigated whether V1 drives chemotherapy resistance and potentially predicts gemcitabine + cisplatin failure and discovered that splice variant (V1) of HYAL-4 is a first-in-class eukaryotic chondroitinase (Chase), and CD44 is its major substrate. Expand
Molecular Biomarkers and Treatments for Renal Cell Carcinoma
TLDR
Finding optimal biomarkers will help tailor targeted therapies according to tumor and patient innate molecular factors and provide the best individualized treatments that can prolong survival while minimizing adverse side effects. Expand
EXPRESSION AND FUNCTION OF A NOVEL CHONDROITINASE IN BLADDER CANCER: MP48‐01
TLDR
In a large, centrally-maintained, standardized database, RP was shown to have a longer operative time to complete, but has significantly decreased post-operative complications and reduced length of stay when compared with OP. Expand