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British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if untreated, often leads to cirrhosis, liver failure and death. Major advances were made in its management based on… Expand
Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience.
BACKGROUND/AIMS Though emergency liver transplantation (ELT) is an established treatment for severe acute liver failure (ALF), outcomes are inferior to elective surgery. Despite prioritization, many… Expand
Management and outcome of pregnancy in autoimmune hepatitis
BACKGROUND There is a paucity of data in the literature on the risks associated with, and optimal management of, pregnancy in patients with autoimmune hepatitis (AIH). AIMS To assess maternal and… Expand
Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: Implications for follow‐up and screening
Hepatocellular carcinoma (HCC) has traditionally been considered a rare complication of cirrhosis secondary to autoimmune hepatitis (AIH), yet the true incidence remains unknown due to a lack of… Expand
Outcomes of pregnancy in women with autoimmune hepatitis.
INTRODUCTION Optimal management during pregnancy of patients with autoimmune hepatitis (AIH) remains undefined. We therefore reviewed all patients with AIH who reported pregnancy at our centre to… Expand
Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari syndrome.
BACKGROUND & AIMS Budd-Chiari Syndrome (BCS) results from obstruction to hepatic venous outflow, with myeloproliferative disorder (MPD) accounting for up to 40% of cases. A number of BCS cases… Expand
Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid.
UNLABELLED BACKGROUND, & AIMS: Studies of primary biliary cirrhosis (PBC) phenotypes largely have been performed using small and selected populations. Study size has precluded investigation of… Expand
Chronic mesenteric venous thrombosis: evaluation and determinants of survival during long-term follow-up.
- D. Orr, P. Harrison, +5 authors M. Heneghan
- Clinical gastroenterology and hepatology : the…
BACKGROUND & AIMS The natural history of chronic portomesenteric (PM) and portosplenomesenteric (PSM) venous thrombosis is defined poorly. Therapeutic options are limited, and are directed at the… Expand
Prognosis of acute severe autoimmune hepatitis (AS-AIH): the role of corticosteroids in modifying outcome.
BACKGROUND & AIMS No standardised definition exists for acute, severe AIH (AS-AIH). However, rapid identification of AS-AIH and early corticosteroid therapy may prevent the need for liver… Expand
Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.
IMPORTANCE Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation of variant transthyretin, induces progressive peripheral nerve deficits and disability. Diflunisal, a… Expand