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Tetraspanin functions and associated microdomains
  • M. Hemler
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 October 2005
TLDR
Important new genetic evidence has now emerged, and is bolstered by new insights into the cell biology, signalling and biochemistry of tetraspanins, that provide a framework for better understanding of these mysterious molecules in the regulation of cellular processes. Expand
Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain.
  • M. Hemler
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • 28 November 2003
This review summarizes key aspects of tetraspanin proteins, with a focus on the functional relevance and structural features of these proteins and how they are organized into a novel type of membraneExpand
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
TLDR
Comparison transcriptomic analyses of mouse LNSC subsets demonstrated the expression of important immune mediators, growth factors and previously unknown structural components in hematopoietic and stromal subsets, suggesting a complex web of crosstalk. Expand
VLA proteins in the integrin family: structures, functions, and their role on leukocytes.
  • M. Hemler
  • Biology, Medicine
  • Annual review of immunology
  • 1990
Article de synthese sur les roles des integrines β1 (proteines VLA) comme recepteurs dans l'adherence des leucocytes a la matrice extracellulaire et comme recepteurs dans l'adherence cellule a cellule
Transmembrane-4 Superfamily Proteins Associate with Activated Protein Kinase C (PKC) and Link PKC to Specific β1 Integrins*
TLDR
The proposed PKC-TM4SF-integrin structures represent a novel type of signaling complex that helps to explain why the integrin α3 extracellular domain is needed for both intracellular PKC recruitment andPKC-dependent phosphorylation of the α3 integrin cytoplasmic tail. Expand
VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site
TLDR
The VCAM-1/VLA-4 ligand-receptor pair may play a major role in the recruitment of mononuclear leukocytes to inflammatory sites in vivo. Expand
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
TLDR
The results show that VLA-4 is a versatile integrin that can mediate tethering, rolling, and firm arrest on VCAM-1. Expand
Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions.
TLDR
The results suggest that homophilic CD147 interactions may play a key role in M MP-2 production and tumor cell invasion, and that perturbation of this molecule may have potential therapeutic uses in the prevention of MMP-1-dependent cancer metastasis. Expand
Functional domains in tetraspanin proteins.
TLDR
Five distinct tetraspanin regions have now been delineated linking structural features to specific functions, including a variable region that mediates specific interactions with other proteins, as well as a more highly conserved region that has been suggested to mediate homodimerization. Expand
Integrin associated proteins.
  • M. Hemler
  • Biology, Medicine
  • Current opinion in cell biology
  • 1 October 1998
TLDR
New evidence suggests that TM4SF proteins may act as linkers between extracellular integrin alpha chain domains and intracellular signaling molecules, such as phosphatidylinositol 4-kinase and protein kinase C. Expand
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