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Osteoarthritis of the knee: association between clinical features and MR imaging findings.
Findings of this study indicate that only two associations exist between clinical symptoms and structural findings found on MR images in patients with OA of the knee.
Early changes in lapine menisci during osteoarthritis development: Part I: cellular and matrix alterations.
- M. Hellio le Graverand, E. Vignon, I. Otterness, D. Hart
- Biology, MedicineOsteoarthritis and cartilage
It is demonstrated that after ACL transection, extracellular matrix deposition as well as altered matrix organization and altered cell distribution occur early in the medial meniscus.
The cells of the rabbit meniscus: their arrangement, interrelationship, morphological variations and cytoarchitecture
Four major morphologically distinct classes of cells were identified within the adult rabbit meniscus using antibodies to cytoskeletal proteins to support the supposition that their specific characteristics underlie the ability of the meniscs to respond to different types of environmental mechanical loads.
Early changes in lapine menisci during osteoarthritis development: Part II: molecular alterations.
Evaluated changes occurring in both medial and lateral menisci from the knees of anterior cruciate ligament (ACL) transected rabbits at 3 and 8 weeks post-surgery show that after ACL transection complex molecular changes, as well as apoptosis, occur early, particularly in the medial meniscus.
Definition of osteoarthritis on MRI: results of a Delphi exercise.
Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort.
Formation and phenotype of cell clusters in osteoarthritic meniscus.
- M. Hellio le Graverand, P. Sciore, J. B. Rattner
- Biology, MedicineArthritis & Rheumatism
- 1 August 2001
The morphologic appearance as well as the type X collagen expression phenotype of the meniscal cells forming the clusters is similar to that of hypertrophic chondrocytes, which provides a basis for understanding the origin of cell clusters in other joint connective tissues, such as osteoarthritic cartilage.
A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
- M. Hellio le Graverand, R. Clemmer, E. Vignon
- MedicineAnnals of the Rheumatic Diseases
- 10 November 2012
Cindunistat (50 or 200 mg/day) did not improve joint pain or function, but was generally well tolerated and iNOS inhibition did not slow OA progression in KLG3 patients.
Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study
The total ROA score of GARP patients, representing cartilage abnormalities at the most prevalent ROA joint locations, showed an excellent correlation with UCTX-II levels, which may be a sensitive quantitative marker of ROA.