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Ghrelin induces adiposity in rodents
It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance.
Serum immunoreactive-leptin concentrations in normal-weight and obese humans.
- R. Considine, M. Sinha, T. L. Bauer
- Medicine, BiologyThe New England journal of medicine
- 1 February 1996
Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production.
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Circulating ghrelin levels are decreased in human obesity.
- M. Tschöp, C. Weyer, P. Tataranni, V. Devanarayan, E. Ravussin, M. Heiman
- Medicine, BiologyDiabetes
- 1 April 2001
Plasma ghrelin concentration was decreased in obese Caucasians as compared with lean Caucasians and was lower in Pima Indians, a population with a very high prevalence of obesity, compared with Caucasians.
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
Ghrelin is considered a gastrointestinal peptide contributing to the regulation of diverse functions of the gut-brain axis and there is indeed a possibility that ghrelin analogs, acting as either agonists or antagonists, might have clinical impact.
Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure
- W. Banks, M. Tschöp, S. M. Robinson, M. Heiman
- BiologyJournal of Pharmacology and Experimental…
- 1 August 2002
It is shown that ghrelin transport across the blood-brain barrier is a complex, highly regulated bidirectional process, defining a new role for the unique post-translational octanoylation.
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.
Reductions of circulating insulin and leptin and increased ghrelin concentrations, as demonstrated in this study, could lead to increased caloric intake and ultimately contribute to weight gain and obesity during chronic consumption of diets high in fructose.
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
- M. Sinha, J. Ohannesian, J. F. Caro
- Medicine, BiologyThe Journal of clinical investigation
- 1 March 1996
The nocturnal rise in leptin observed in the present study resembles those reported for prolactin, thyroid-stimulating hormone, and free fatty acids and is speculated to have an effect in suppressing appetite during the night while sleeping.
GOAT links dietary lipids with the endocrine control of energy balance
Ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylated substrates and links ingested lipids to energy expenditure and body fat mass.