Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment
HGH and its C-terminal fragment reduce body weight gain, increase fat oxidation, and stimulate lipolysis in obese mice, yet AOD9604 does not interact with the hGH receptor.
Effects of exposure temperature on brown adipose tissue uncoupling protein mRNA levels.
- K. Freeman, M. Heffernan, Z. Dhalla, H. Patel
- Biology, PhysicsBiochemistry and cell biology = Biochimie et…
- 1 February 1989
It is suggested that in warm-acclimated rats, a maximal response to a cold stimulus in brown adipose tissue is reached by 19 degrees C, which suggests that the amount of protein reflects the mRNA levels during later times but not the initial time of exposure to cold.
Studies On The Use Of “Slimax”, A Chinese Herbal Mixture, In The Treatment Of Human Obesity
- V. Ignjatovic, E. Ogru, M. Heffernan, R. Libinaki, Y. Lim, F. Ng
- BiologyPharmaceutical Biology
- 1 January 2000
Treatment with Slimax resulted in a significant decrease in parameters such as body weight, waist and hip circumference, and Body Mass Index, in all subjects tested.
The conformational and biological analysis of a cyclic anti-obesity peptide from the C-terminal domain of human growth hormone.
Comparison of the conformation of this peptide with residues 177-191 in the native hGH protein X-ray crystal structure indicates that the synthetic peptide retains some structural similarity to the intact protein.
Short-term effects of recombinant human insulin-like growth factor I on metabolic control of patients with type II diabetes mellitus.
- D. Schalch, N. Turman, V. S. Marcsisin, M. Heffernan, H. Guler
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 December 1993
It is concluded that short-term treatment of type II diabetic patients with rhIGF-I favorably affects metabolic control and enhances kidney function.
Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism.
- M. Heffernan, W. J. Jiang, A. Thorburn, F. Ng
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 September 2000
It is indicated that oral administration of AOD-9401 alters lipid metabolism in adipose tissue, resulting in a reduction of weight gain in obese animals, and this small synthetic hGH peptide has potential in the treatment of human obesity.
The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice.
It is described how hGH and AOD9604 can reduce body weight and body fat in obese mice following 14 d of chronic ip administration and increases in the level of expression of β3-AR RNA, the major lipolytic receptor found in fat cells.
Effects of Genetic and Diet‐Induced Obesity on Lipid Metabolism
- R. Libinaki, M. Heffernan, F. Ng
- BiologyIUBMB Life - A Journal of the International Union…
- 1 July 1999
The lard‐fed mice appeared to have significantly higher body weight in this 34‐day period than that of the other two groups fed on the Normal diet.
A decision-support tool to inform Australian strategies for preventing suicide and suicidal behaviour.
- A. Page, J. Atkinson, M. Heffernan, G. McDonnell, I. Hickie
- PsychologyPublic Health Research & Practice
- 27 April 2017
The value of dynamic modelling methods for managing complexity and uncertainty is highlighted, and their potential use as a decision-support tool for policy makers and program planners for community suicide prevention actions is demonstrated.
A decision support tool to inform local suicide prevention activity in Greater Western Sydney (Australia)
- A. Page, J. Atkinson, I. Hickie
- Psychology, MedicineAustralian and New Zealand journal of psychiatry…
- 19 April 2018
The development of a decision support tool to identify the combination of suicide prevention activities and service priorities likely to deliver the greatest reductions in suicidal behaviour in Western Sydney over the period 2018–2028 is described.