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Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
The transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature are reported, offering an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems.
Substrate-Controlled Succession of Marine Bacterioplankton Populations Induced by a Phytoplankton Bloom
The bacterioplankton response to a diatom bloom in the North Sea is investigated and a dynamic succession of populations at genus-level resolution is observed, revealing how planktonic species, despite their seemingly homogeneous habitat, can evade extinction by direct competition.
Essential Bacillus subtilis genes
- K. Kobayashi, S. Ehrlich, N. Ogasawara
- BiologyProceedings of the National Academy of Sciences…
- 7 April 2003
To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, a systematic inactivation of Bacillus subtilis genes was carried out and most genes involved in the Embden–Meyerhof–Parnas pathway are essential.
Heat‐shock and general stress response in Bacillus subtilis
The induction of stress proteins is an important component of the adaptional network of a non‐growing cell of Bacillus subtilis and they are proposed to provide general and rather non‐specific protection of the cell under these adverse conditions.
SigB-dependent general stress response in Bacillus subtilis and related gram-positive bacteria.
One of the strongest and most noticeable responses of Bacillus subtilis cells to a range of stress and starvation stimuli is the dramatic induction of about 150 SigB-dependent general stress genes.…
Repair of Global Regulators in Staphylococcus aureus 8325 and Comparative Analysis with Other Clinical Isolates
The repaired RN1 is a good model strain for studies of staphylococcal regulation and pathobiology; although strain Newman has been used extensively for such studies in recent years, it has a missense mutation in saeS, the histidine kinase component of the sae signaling module, which profoundly alters its regulatory phenotype.
Gene regulatory network inference: Data integration in dynamic models - A review
Proteomics of Protein Secretion by Bacillus subtilis: Separating the “Secrets” of the Secretome
- H. Tjalsma, H. Antelmann, J. V. van Dijl
- BiologyMicrobiology and Molecular Biology Reviews
- 1 June 2004
Proteomics has yielded a variety of novel leads for the analysis of protein traffic in B. subtilis and other gram-positive bacteria, which will serve to increase the understanding of virulence factor biogenesis in gram- positive pathogens, which is likely to be of high medical relevance.
Analysis of the induction of general stress proteins of Bacillus subtilis.
The quantification of the mRNA and the analysis of the protein synthesis pattern support the initial hypothesis that the chaperones DnaK and GroEL are Hsps in B. subtilis, and indicate that SigB plays a crucial role in the induction of general stress genes, but is dispensable for the induction for heat-specific stress proteins.
A proteomic view on genome-based signal peptide predictions.
In the present studies, proteomic approaches were used to define the extracellular complement of the B. subtilis secretome and show that genome-based predictions reflect the actual composition of theextracellular proteome for approximately 50%.