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Impact of temperature on the dynamics of the COVID-19 outbreak in China
The overall epidemic intensity of COVID-19 reduced slightly following days with higher temperatures with a relative risk (RR) was 0.96 (95% CI: 0.93, 0.99), and a random-effect meta-analysis confirmed the statistically significant association between temperature and RR during the study period.
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
In vitro and in vivo studies indicated that ectopic expression of miR-181b significantly promoted apoptosis and inhibited viability/proliferation of leukemic cells and delayed leukemogenesis; such effects could be reversed by forced expression of PBX3.
Trends in the incidence of 15 common cancers in Hong Kong, 1983-2008.
These trends in cancer morbidity can be used as an important resource to plan and develop effective programs aimed at the control and prevention of the spread of cancer amongst the Hong Kong population.
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
The results uncover a previously unappreciated miRNA-regulation mechanism by which a single miRNA may target both oncogenes and tumour suppressors, simultaneously, or, sequentially, in tumourigenesis and normal development per cell differentiation, indicating that miRNA regulation is much more complex than previously thought.
Silencing of estrogen receptor α (ERα) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer
  • Lin Zhao, L. Wang, +7 authors M. Wei
  • Biology, Medicine
    Breast Cancer Research and Treatment
  • 1 September 2009
It is demonstrated for what is believed to be the first time, that ERα methylation occurs in high frequency and is one of the mechanisms of ERα expression silence in a subset of sporadic breast cancers from Chinese women.
Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose.
Oral administration of EGCG significantly improved the cognitive deficits in mice and elevated T-SOD and GSH-Px activities, decreased MDA contents in the hippocampus, and reduced the cell apoptosis index and expression of cleaved caspase-3 in the mouse hippocampus.
The microRNA expression changes associated with malignancy and SDHB mutation in pheochromocytoma.
The data suggest that misexpression of miR-483-5p, mi-101, and mi-183 is associated with malignant pheochromocytoma, and area under the receiver operating curve (AUC) analysis indicated that these miRNAs could be useful diagnostic markers for distinguishing malignant from benign phechromocyTomas.
Ano1/TMEM16A Overexpression Is Associated with Good Prognosis in PR-Positive or HER2-Negative Breast Cancer Patients following Tamoxifen Treatment
Ano1 may be a potential marker for good prognosis in PR-positive or HER2-negative patients following tamoxifen treatment and the PR and HER2 status defines a subtype of breast cancer in which Ano1 overexpression is associated with good prog diagnosis and prognosis followingTamoxifens treatment.
PM2.5‐induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells
Particulate matter 2.5 (
Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice
MEM treatment activated the NGF/TrkA signaling, and inhibited the p75(NTR) signaling in APP/PS1 mice to ameliorate the behavioral deficits and amyloidosis, indicating that NGF signaling was a new potential target of MEM treatment for AD therapy.