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Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor‐independent myeloperoxidase‐inhibiting mechanism
TLDR
Cannabidiol provides potent and long‐lasting neuroprotection through an anti‐inflammatory CB1 receptor‐independent mechanism, suggesting that cannabidio will have a palliative action and open new therapeutic possibilities for treating cerebrovascular disorders.
Delayed Treatment With Minocycline Ameliorates Neurologic Impairment Through Activated Microglia Expressing a High-Mobility Group Box1–Inhibiting Mechanism
TLDR
It is suggested that minocycline inhibits activated microglia expressing HMGB1 and decreases neurologic impairment induced by cerebral ischemia, and will have a palliative action and open new therapeutic possibilities for treatment of postischemic injury via anHMGB1-inhibiting mechanism.
Evaluation of palatability of 10 commercial amlodipine orally disintegrating tablets by gustatory sensation testing, OD‐mate as a new disintegration apparatus and the artificial taste sensor
TLDR
The purpose of this study was to evaluate and compare the palatability of 10 formulations of amlodipine orally disintegrating tablets by means of human gustatory sensation testing, disintegration/dissolution testing and the evaluation of bitterness intensity using a taste sensor.
Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.
TLDR
Warming to 31 degrees C might attenuate both the neuroprotective and hypothermic effects of Delta(9)-THC through inhibiting the increase in CB(1) receptor in both the striatum and cortex but not in the hypothalamus, which may suggest a new thermoregulation mechanism of Delta-9-THC.
miR‐200c‐3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment
TLDR
Combining integrated microarray profiling and single‐cell clone analyses indicates that miR‐200c‐3p in exosomes derived from a highly invasive OSCC line can induce a similar phenotype in non‐invasive counterparts.
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