M. Hayashi

Publications55
h-index17
Citations1,256
Highly Influential Citations11
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Studies on bredinin. I. Isolation, characterization and biological properties.
TLDR
Slight prolongation in the survival period of mice inoculated with lymphatic leukemia L1210 was observed by intraperitoneal injection of bredinin, however, it was not effective on P388 leukemia or EHRLICH ascites tumor.
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STUDIES ON BREDININ. I
TLDR
Slight prolongation in the survival period of mice inoculated with lymphatic leukemia L1210 was observed by intraperitoneal injection of bredinin, however, it was not effective on P388 leukemia or EHRLICH ascites tumor.
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Studies on neplanocin A, new antitumor antibiotic. II. Structure determination.
The structure and stereochemistry of neplanocin A was determined on the basis of its spectral and chemical evidences as [1R-(la,2a,3b)]-3-(6-amino-9-yl)-5-(hydroxy-methyl)-4-cyclopentene-1,2-diol.…
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Mycinamicins, new macrolide antibiotics. I. Taxonomy, production, isolation, characterization and properties.
TLDR
From their physicochemical and biological properties, the mycinamicins are classified as new macrolide antibiotics.
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Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization.
TLDR
Neplanocin A has cytotoxicity against L5178Y cells in culture and showed a remarkable effect on the life prolongation of mice infected with L1210 leukemia.
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Studies on aculeacin. I. Isolation and characterization of aculeacin A.
TLDR
The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity, and has relatively low toxicity in mice.
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Isolation of proposed intermediates in the biosynthesis of mycinamicins
Some proposed intermediates in the biosynthesis of mycinamicins were isolated from the culture filtrate of Micromonospora griseorubida sp. nov and their structures were determined on the basis of…
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Zincphyrin, a novel coproporphyrin III with zinc from Streptomyces sp.
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STUDIES ON ACULEACIN
TLDR
The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity, and has relatively low toxicity in mice.
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Stachybocins, novel endothelin receptor antagonists, produced by Stachybotrys sp. M6222. II. Structure determination of stachybocins A, B and C.
The structures of stachybocins A, B and C, new endothelin receptor antagonist, were determined by NMR spectral analysis using pulse-field-gradient technique. Stachybocin A consists of two…
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