M. Hayashi

Publications223
h-index32
Citations3,369
Highly Influential Citations96
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Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells.
TLDR
Results suggest that C10 releases calcium from intracellular stores via activation of phospholipase C in plasma membrane through activation of calmodulin-dependent actin microfilament, followed by dilatation of the paracellular route.
Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cells.
The mechanism of paracellular expansion by absorption enhancers, e.g., EDTA, sodium caprate (C10), and decanoylcarnitine (DC), was studied, the focus being on the process of actin microfilament…
Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S‐mephenytoin 4′‐hydroxylation
A possibility to predict the absorbability of poorly water-soluble drugs in humans based on rat intestinal permeability assessed by an in vitro chamber method.
Lipopolysaccharide transport system across colonic epithelial cells in normal and infective rat.
TLDR
The possibility that colonic epithelial cells contain specific transport systems for LPS, one of which shows some degree of substrate specificity with the interaction of CD14 and/or that of TLR4 is suggested.
Enhancement of Colonic Drug Absorption by the Transcellular Permeation Route
TLDR
It is suggested that caprate enhances permeability via the transcellular route through membrane perturbation through perturbing to the membrane.
Mechanistic analysis for drug permeation through intestinal membrane.
TLDR
For drug absorption, intestinal drug permeability's through both the paracellular and transcellular routes were analyzed, suggesting changes in TJ as the membrane structure and P-gp as the membranes function are important factors controlling intestinal membrane transport.
The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds.
Transport of acetaminophen conjugates in isolated rat hepatocytes.
TLDR
Changes in the amount of acetaminophen, its glucuronide, and its sulfate in the hepatocytes and medium as a function of time simulated according to the model closely agreed with those actually observed.
Effects of pharmaceutical excipients on membrane permeability in rat small intestine.
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