• Publications
  • Influence
Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion
In differentiating keratinocytes tyrosine phosphorylation plays a positive role in control of cell adhesion, and this regulatory function appears to be important both in vitro and in vivo. Expand
Protein Binding and Functional Characterization of Plakophilin 2
It is demonstrated that plakophilin 2 can interact directly with several desmosomal components, including desmoplakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and 2a, and is able to associate with β-catenin through its head domain, and the expression of plakophon 2 in SW480 cells up-regulates the endogenous β- catenin/T cell factor-signaling activity. Expand
The mitotic-spindle-associated protein astrin is essential for progression through mitosis
Recombinant astrin was purified and characterized, and showed parallel dimers with head-stalk structures reminiscent of motor proteins, although no sequence similarities to known motor proteins were found. Expand
Defining desmosomal plakophilin-3 interactions
Results show that PKP3, whose epithelial and epidermal desmosomal expression pattern and protein interaction repertoire are broader than those of PKP1 and -2, is a unique multiprotein binding element in the basic architecture of a vast majority of epithelial desmosomes. Expand
Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?
  • M. Hatzfeld
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2007
This review aims to summarize the current knowledge of plakophilin function in the context of cell adhesion, signaling and their putative role in diseases. Expand
ZBP1 regulates mRNA stability during cellular stress
It is identified that Zipcode-binding protein 1 (ZBP1) regulates the cytoplasmic fate of specific mRNAs in nonstressed cells and is a key regulator of mRNA turnover during the ISR, which is essential for translational adaptation during cellular stress by modulating mRNA turnover. Expand
Pair formation and promiscuity of cytokeratins: formation in vitro of heterotypic complexes and intermediate-sized filaments by homologous and heterologous recombinations of purified polypeptides
The results show that cytokeratin complex and IF formation in vitro requires the pairing of one representative of each the type I and type II subfamilies into the heterotypic tetramer but that there is no structural incompatibility between any of the members of the two subfam families. Expand
Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins.
Cl cloning of a cDNA encoding a new armadillo family member, p0071, closely related to p120 and B6P/plakophilin and more distantly related to armadello, plakoglobin, beta-catenin and other members of the gene family is reported. Expand
The armadillo protein p0071 regulates Rho signalling during cytokinesis
It is shown that the armadillo protein p0071, unlike its relative p120ctn, is localized at the midbody during cytokinesis and is essential for cell division. Expand
Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics.
The data suggest that certain cytokeratin polypeptides are complementary and contain sequences that direct their association into specific complexes forming IF subunits, and that cytokeratins do not form complexes with vimentin, another type of IF protein. Expand