• Publications
  • Influence
Prolactin proteolysis by glandular kallikrein: in vitro reaction requirements and cleavage sites, and detection of processed prolactin in vivo.
TLDR
The hypothesis that GK may function to process PRL to novel forms in rat lactotrophs is supported, with the ability of GK to cleave PRL in vitro supported. Expand
Effects of dietary fish oil on fatty acids and eicosanoids in metastasizing human breast cancer cells.
TLDR
The strong correlation between phospholipid LA levels and metastasis and the lack of an association with tumor eicosanoids suggest that the 18% MO diet inhibited metastasis because dietary LA was replaced by other fatty acids. Expand
Effects of phenobarbital and 3-methylcholanthrene induction on the formation of three glucuronide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NNK.
TLDR
The metabolism of NNK to alpha-hydroxymethylNNK-Gluc is compared by PB induced, 3-methylcholanthrene (3-MC) induced and control rat hepatocytes to find an explanation for the decrease in NNK hemoglobin adducts, which may be a PB induced increase in the glucuronidation of alpha-Hydroxylation, the metabolite responsible for adduct formation. Expand
Myocardial Salvage Induced by REV‐5901: An Inhibitor and Antagonist of the Leukotrienes
TLDR
It is proposed that inhibition of leukotriene B4 formation by REV-5901 suppresses the accumulation of neutrophils, thereby attenuating neutro-phil-mediated cardiac damage. Expand
Effect of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice.
TLDR
Three different levels of dietary linoleic acid intake were determined on the growth of MDA-MB-435 human breast cancer cells in the mammary fat pads of nude mice, and their metastasis to the lungs, and the incidence of grossly visible pulmonary metastatic nodules was higher for both groups compared with the 2% LA-fed group. Expand
Dietary fatty acids and breast cancer invasion and metastasis.
TLDR
It is concluded that the utilization of appropriate dietary interventions and pharmacological inhibitors offers a promising approach to suppress metastasis. Expand
A neutrophil-derived cytochrome P450-dependent metabolite of arachidonic acid modulates neutrophil behavior.
TLDR
Peak 2 may modulate some activities of canine PMNs because the biologic activity of Peak 2 is opposite to that of LTB4, which promotes PMN aggregation and adhesion, and because L TB4 may be metabolized by a cytochrome P-450-dependent mixed function oxidase to less active metabolites, this enzyme system may play a central role in the control of PMN function. Expand
Differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene
TLDR
The results document that both TAM and TACE exhibit protein-specific estrogen agonist and antagonist efficacies in lactotrophs, with the estrogen induction of glandular kallikrein being particularly sensitive to antagonism by TAM in vivo. Expand
Dynamics of estrogen induction of glandular kallikrein in the rat anterior pituitary.
TLDR
The dynamics of the estrogen induction of glandular kallikrein resembled theosterone induction of uterine dry weight with regard to estrogen sensitivity and the presence of a lag phase before estrogen-induced increases, however, uterinedry weight responded more rapidly to estrogen than did anterior pituitary glandularKallikREin, and reached a plateau after 5 days of estrogen treatment. Expand
Biological thiols elicit prolactin proteolysis by glandular kallikrein and permit regulation by biochemical pathways linked to redox control.
TLDR
Thioredoxin (a protein disulfide oxidoreductase) potently elicited PRL proteolysis by GK in the presence of a reducing shuttle and Triton X-100, and PRL cleavage could be controlled by substrates, enzymes, and cofactors making up the reducing shuttle when GSSG was used. Expand
...
1
2
...