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Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis
TLDR
Genetic epistasis analysis is used to identify proteinase-activated receptor (PAR)-2-dependent inflammatory signaling as an essential component of matriptase-mediated oncogenesis and suggests dual induction of PAR-2-NFκB inflammatory signaling and PI3K-Akt-mTor survival/proliferative signaling may contribute to pro-tumorigenic signaling in human epithelial carcinogenesis.
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors
TLDR
Results indicate that quantitative and/or qualitative alteration in phosphatase activity determines the transforming potential as well as target cell/tissue spectrum of individual SHP-2 mutants as oncoproteins.
Transient induction of IL‐2 receptor in cultured T cell lines by HTLV‐1 LTR‐linked tax‐1 gene.
TLDR
The experimental data suggest that the observed heterogeneity in IL‐2R alpha expression in the transformants is due to a cell‐cycle‐regulated expression and function of tax‐1.
EFFECT OF INTRASPLENIC INJECTION OF ALLOGENEIC BONE MARROW CELLS ON THE SURVIVAL OF LETHALLY X‐IRRADIATED MICE
TLDR
It was suggested that lymphoid cells of donor origin were predominantly identified in almost all BALB/c or C3H/He recipients which were inoculated i.v.s. with bone marrow cells from C5BL/6 mice.
Abstract 1916: Integrative analysis of DNA copy number and gene expression in oropharyngeal squamous cell carcinomas .
TLDR
Biological markers as potential predictors of response to chemo and radiotherapy according to HPV infection in oropharyngeal carcinomas are investigated to find functionally relevant molecular drivers and targets for therapy.
Abstract 1145: Molecular markers of neoadjuvant chemotherapy and combined chemoradiotherapy response in patients with oropharynx squamous cell carcinoma
TLDR
It was detected specific chromosomal imbalances associated with therapy response and consequently, putative candidates to be validated in a large series of cases.
Abstract 4256: Methylation profile in penile carcinomas reveal distinct signatures according to HPV status.
TLDR
Methylation profile in penile carcinomas reveal distinct signatures according to HPV status, and the global levels of methylation in repetitive regions revealed to be lower in tumor samples than previously reported.
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