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Graded persistent activity in entorhinal cortex neurons
It is shown that individual neurons from layer V of the entorhinal cortex—which link the hippocampus to extensive cortical regions—respond to consecutive stimuli with graded changes in firing frequency that remain stable after each stimulus presentation, which constitutes an elementary mechanism for working memory.
A Proposed Function for Hippocampal Theta Rhythm: Separate Phases of Encoding and Retrieval Enhance Reversal of Prior Learning
A hippocampal model shows how theta rhythm could be important for reversal in this task by providing separate functional phases during each 100-300 msec cycle, consistent with physiological data.
Properties and role of I(h) in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons.
- C. Dickson, J. Magistretti, M. Shalinsky, E. Fransén, M. Hasselmo, A. Alonso
- BiologyJournal of neurophysiology
- 1 May 2000
Results indicated that the interplay between I(NaP) and I(h) can sustain persistent subthreshold oscillations in SCs, which are thought to be instrumental in implementing theta rhythmicity in the entorhinal-hippocampal network.
The role of acetylcholine in learning and memory
- M. Hasselmo
- Biology, PsychologyCurrent Opinion in Neurobiology
- 1 December 2006
Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition
Evidence indicates that changes in cholinergic modulation on a timescale of seconds is triggered by sensory input cues and serves to facilitate cue detection and attentional performance.
Temporal Frequency of Subthreshold Oscillations Scales with Entorhinal Grid Cell Field Spacing
Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.
Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
Neuromodulation: acetylcholine and memory consolidation
- M. Hasselmo
- Biology, PsychologyTrends in Cognitive Sciences
- 1 September 1999
The role of expression and identity in the face-selective responses of neurons in the temporal visual cortex of the monkey
Gamma frequency-range abnormalities to auditory stimulation in schizophrenia.
These data provide new information on selective deficits in early-stage sensory processing in schizophrenia, a failure to support the entrainment of intrinsic gamma-frequency oscillators.