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Identification of Mammalian Vps24p as an Effector of Phosphatidylinositol 3,5-Bisphosphate-dependent Endosome Compartmentalization*
The use of cDNA phage libraries in conjunction with synthetic biotinylated derivatives of phosphatidylinositol 3,5-bisphosphate in the identification of a mammalian phosphate-binding protein, mVps24p, is reported, providing the first direct link between phosphate-based lipid found in eukaryotes and the protein machinery involved in the production of the class-E cellular phenotype. Expand
Anthocyanin-rich purple potato flake extract has antioxidant capacity and improves antioxidant potential in rats
The present results suggest that purple potato flakes have antioxidant functions with regard to radical scavenging activity and inhibition of linoleic acid oxidation, and that they improve the antioxidant potentials in rats by enhancing hepatic Mn-SOD, Cu/Zn-S OD and GSH-Px mRNA expression. Expand
Structural Elucidation of 4-(Cystein-S-yl)butyl Glucosinolate from the Leaves of Eruca sativa
The structurally unique glucosinolate (GSL), 4-(cystein-S-yl)butyl DS-GSL, was identified in the leaves of hydroponically-grown rocket salad and clearly seems to reduce the detoxification of excess NH4 + in the Leaves of rocket salad. Expand
Identification of csypyrone B2 and B3 as the minor products of Aspergillus oryzae type III polyketide synthase CsyB.
Since our first report on the identification of the fungal type III polyketide synthase (PKS) genes csyA~D in Aspergillus oryzae RIB40, type III PKS homologues have also been found in other fungalExpand
Indole-3-Acetic Acid Produced by Burkholderia heleia Acts as a Phenylacetic Acid Antagonist to Disrupt Tropolone Biosynthesis in Burkholderia plantarii
A non-antibacterial metabolite from the culture fluid of B. heleia PAK1-2 was isolated that was able to suppress B. plantarii virulence and subsequently identified as indole-3-acetic acid (IAA), suggesting that IAA inhibited steps of tropolone biosynthesis. Expand
Fungal type III polyketide synthases.
Homology modelling reported in this article supports the importance of the capacity of the acyl binding tunnel and active site cavity in fungal type III PKSs. Expand
Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage
The results suggest that betalains can protect cells from nitrosative stress in addition to protecting them from oxidative stresses. Expand
Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis.
The early biosynthetic steps after the formation of FD were investigated and Orf1 is suggested to be an 8beta-hydroxylation enzyme that yields FD 8 beta-ol, followed by 16-hydrogenation by Orf7 to produce FD 8beta16-diol. Expand
Synthesis of Methoxy-Substituted Diazirinyl Phenylalanine – A Novel Photoreactive Aspartame Derivative for Functional Analysis of Sweet Receptors
Photoreactive phenylalanine derivatives are well known as functional analysis reagents for target biomolecules. The photophores are commonly introduced at 4-position on benzene. Aspartame, whichExpand
Effect of Pamamycin-607 on Secondary Metabolite Production by Streptomyces spp.
Results demonstrate that pamamycin-607 not only restored or stimulated aerial mycelium formation, but also stimulated secondary metabolite production. Expand