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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
Results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH show clinically significant histological improvement that is reasonably likely to predict clinical benefit. Expand
Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension.
The epidemiology, pathogenesis, diagnosis, management, and prognosis ofodular regenerative hyperplasia are detailed. Expand
Serum chemerin and vaspin in non-alcoholic fatty liver disease
- M. Kukla, K. Żwirska-Korczala, +7 authors R. Bułdak
- Scandinavian journal of gastroenterology
- 23 January 2010
It is shown for the first time that chemerin and vaspin serum concentrations are altered in patients with NAFLD, and the analyzed adipokines appear to play a pivotal role in the pathogenesis of NAFLd, not only as regulators of insulin sensitivity, but also as mediators of the inflammatory process. Expand
Serum adipokines in inflammatory bowel disease.
- M. Waluga, M. Hartleb, G. Boryczka, M. Kukla, K. Żwirska-Korczala
- World journal of gastroenterology
- 14 June 2014
IBD modulates serum adipokine levels by increasing resistin and visfatin release and suppressing leptin production and also was not altered by anti-inflammatory therapy. Expand
Procalcitonin and macrophage inflammatory protein-1 beta (MIP-1β) in serum and peritoneal fluid of patients with decompensated cirrhosis and spontaneous bacterial peritonitis.
- M. Lesińska, M. Hartleb, K. Gutkowski, E. Nowakowska-Duława
- Advances in medical sciences
- 1 March 2014
MIP-1β concentration in ascitic fluid may distinguish patients with and without SBP with satisfactory sensitivity and specificity and Chemokines should be further explored for diagnostic use. Expand
Coagulopathy in liver diseases.
A complicated issue of multiple coagulopathies in patients with advanced liver dysfunction is discussed, including thrombocytopenia, chronic disseminated intravascular coagulation, accelerated fibrinolysis, hypofibrinogenemia and dysfibr inogenemia. Expand
Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
A 24-year-old female who was given pulsed MT therapy for multiple sclerosis and developed Hepatotoxicity developed several weeks after drug exposure, and the causal association with MT was confirmed by unintentional rechallenge test. Expand
Kidneys in chronic liver diseases.
Hepatorenal syndrome is initiated by progressive portal hypertension, and may be prematurely triggered by bacterial infections, nonbacterial systemic inflammatory reactions, excessive diuresis, gastrointestinal hemorrhage, diarrhea or nephrotoxic agents. Expand
A composite model including visfatin, tissue polypeptide-specific antigen, hyaluronic acid, and hematological variables for the diagnosis of moderate-to-severe fibrosis in nonalcoholic fatty liver…
- Alina Chwist, M. Hartleb, A. Lekstan, M. Kukla, K. Gutkowski, M. Kajor
- Polskie Archiwum Medycyny Wewnetrznej
New laboratory variables with a predictive potential to detect advanced fibrosis (stages 2 and 3) in NAFLD are investigated and a scoring system based on these variables allows to predictAdvanced fibrosis with high sensitivity and specificity. Expand
Differentiation of pancreatobiliary cancer from benign biliary strictures using neutrophil gelatinase-associated lipocalin.
- A. Budzyńska, E. Nowakowska-Duława, T. Marek, H. Bołdys, A. Nowak, M. Hartleb
- Journal of physiology and pharmacology : an…
- 1 February 2013
It is concluded that measurement of biliary, but not serum NGAL, may differentiate malignant pancreatobiliary from benign biliary strictures, serving as a complementary biomarker for serum CA19-9. Expand