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26,27-Hexafluoro-1,25-dihydroxyvitamin D3 (F6-1,25(OH)2D3) prevents osteoporosis induced by immobilization combined with ovariectomy in the rat.
TLDR
The pharmacological effective dose of F6-1,25(OH)2D3 was considered to prevent the osteoporotic decrease of bone mass by suppressing the elevated bone turnover.
Differences in metabolism between 26,26,26,27,27,27-hexafluoro-1 alpha, 25-dihydroxyvitamin D3 and 1 alpha, 25-dihydroxyvitamin D3 in cultured neonatal mouse calvaria.
TLDR
The high potency of ST-630 in stimulating bone resorption in organ culture may be associated with a difference between ST- 630 and 1,25(OH)2D3 in the mode of metabolism in the cultured bones.
Calcium regulating activity of 26,27-dimethyl analog of 24R,25-dihydroxyvitamin D3
TLDR
It is suggested that the basis for a similarity in potency between 1,24R,25-trihydroxy-26,27-dimethylvitamin D3 and 24,25(OH)2D3 or its dimethyl analog in vitamin D-deficient rats is likely the result of 1 α-hydroxylation.
Effects on cultured neonatal mouse calvaria of 1α,25-dihydroxyvitamin D3,26,26,26,27,27,27-hexafluoro-1α,25-dihydroxyvitamin D3 and 26,26,26,27,27,27-hexafluoro-1α,23S,25-trihydroxyvitamin D3
TLDR
It is suggested that the higher potency of 26,27-F 6 -1,25(OH) 2 D 3 in bone resorption in vitro may be due at least in part to both the higher strength in osteoclast formation and the larger retention in calvariae.
Calcium regulating activity of 24a-homo-24,24-difluoro-1α,25-dihydroxyvitamin D3 and 26,27-dimethyl-24,24-difluoro-1α,25-dihydroxyvitamin D3
SummaryTwo fluoro analogs of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], 24a-homo-24,24-difluoro-1α,25-dihydroxyvitamin D3 [24aF2-homo-1,25(OH)2D3], and
Calcium regulating activity of 26,27-dialkyl analogs of 1α,25-dihydroxyvitamin D3
SummaryA series of analogs of 1α,25-dihydroxyvitamin D3[1,25(OH)2D3] with alkyl substitutions in 26- and 27-positions were tested for calcium (Ca) regulating activity. The potencies of dialkyl
Effects on cultured neonatal mouse calvaria of 1 alpha,25-dihydroxyvitamin D3, 26,26,26,27,27,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 26,26,26,27,27,27-hexafluoro-1
TLDR
It is suggested that the higher potency of 26,27-F6-1,25(OH)2D3 in bone resorption in vitro may be due at least in part to both theHigher potency of 25,26,26-F 6-1-25( OH)2 D3 in osteoclast formation and the larger retention of 27,27,F6,1,23,25 (OH)3D3In calvariae.
Calcium regulating activity of 24a-homo-24,24-difluoro-1 alpha,25-dihydroxyvitamin D3 and 26,27-dimethyl-24,24-difluoro-1 alpha,25-dihydroxyvitamin D3.
TLDR
Fluoro substitution in 24-position of 1,25(OH)2D3 apparently does not alter activities of the original compounds, that is, 26,27-dimethyl 1 alpha,25-dihydroxyvitamin and its fluoro analogs in bone Ca mobilization and stimulating activities of osteoclast-like cell formation.
Comparison of 26,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3 on the resorption of bone explants ex vivo.
26,27-Hexafluoro-1 alpha,25-dihydroxyvitamin D3 [F6-1,25-(OH)2D3] is more potent than 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] in stimulating bone resorption in vitro and in vivo. The reason why
Elongation of the side chain of analogs of 1α,25-dihydroxyvitamin D3 prevents osteopenia in a rat model
TLDR
Five analogs of 1α,25-dihydroxyvitamin D3 were investigated to clarify the possibility that prevents osteopenia induced in rats by ovariectomy and sciatic neurotomy to determine whether these analogs may be effective for treatment of subjects with osteoporosis.
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