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26,27-Hexafluoro-1,25-dihydroxyvitamin D3 (F6-1,25(OH)2D3) prevents osteoporosis induced by immobilization combined with ovariectomy in the rat.

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Differences in metabolism between 26,26,26,27,27,27-hexafluoro-1 alpha, 25-dihydroxyvitamin D3 and 1 alpha, 25-dihydroxyvitamin D3 in cultured neonatal mouse calvaria.

The high potency of ST-630 in stimulating bone resorption in organ culture may be associated with a difference between ST- 630 and 1,25(OH)2D3 in the mode of metabolism in the cultured bones.
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Calcium regulating activity of 26,27-dimethyl analog of 24R,25-dihydroxyvitamin D3

It is suggested that the basis for a similarity in potency between 1,24R,25-trihydroxy-26,27-dimethylvitamin D3 and 24,25(OH)2D3 or its dimethyl analog in vitamin D-deficient rats is likely the result of 1 α-hydroxylation.
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Effects on cultured neonatal mouse calvaria of 1α,25-dihydroxyvitamin D3,26,26,26,27,27,27-hexafluoro-1α,25-dihydroxyvitamin D3 and 26,26,26,27,27,27-hexafluoro-1α,23S,25-trihydroxyvitamin D3

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Effects on cultured neonatal mouse calvaria of 1 alpha,25-dihydroxyvitamin D3, 26,26,26,27,27,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 26,26,26,27,27,27-hexafluoro-1…

It is suggested that the higher potency of 26,27-F6-1,25(OH)2D3 in bone resorption in vitro may be due at least in part to both theHigher potency of 25,26,26-F 6-1-25( OH)2 D3 in osteoclast formation and the larger retention of 27,27,F6,1,23,25 (OH)3D3In calvariae.
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Calcium regulating activity of 26,27-dialkyl analogs of 1α,25-dihydroxyvitamin D3

From these results, the lengthening by one carbon at 26- and 27-positions was shown to maintain the Ca regulatory activity of 1,25(OH)2D3.
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Calcium regulating activity of 24a-homo-24,24-difluoro-1α,25-dihydroxyvitamin D3 and 26,27-dimethyl-24,24-difluoro-1α,25-dihydroxyvitamin D3

Fluoro substitution in 24-position of 1,25(OH)2D3 apparently does not alter activities of the original compounds, hence, the fluoro substitution at 24- position of 1-25( OH)2 D3.
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Calcium regulating activity of 24a-homo-24,24-difluoro-1 alpha,25-dihydroxyvitamin D3 and 26,27-dimethyl-24,24-difluoro-1 alpha,25-dihydroxyvitamin D3.

Fluoro substitution in 24-position of 1,25(OH)2D3 apparently does not alter activities of the original compounds, that is, 26,27-dimethyl 1 alpha,25-dihydroxyvitamin and its fluoro analogs in bone Ca mobilization and stimulating activities of osteoclast-like cell formation.
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Comparison of 26,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3 on the resorption of bone explants ex vivo.

26,27-Hexafluoro-1 alpha,25-dihydroxyvitamin D3 [F6-1,25-(OH)2D3] is more potent than 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] in stimulating bone resorption in vitro and in vivo. The reason why…
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Elongation of the side chain of analogs of 1α,25-dihydroxyvitamin D3 prevents osteopenia in a rat model

Five analogs of 1α,25-dihydroxyvitamin D3 were investigated to clarify the possibility that prevents osteopenia induced in rats by ovariectomy and sciatic neurotomy to determine whether these analogs may be effective for treatment of subjects with osteoporosis.
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