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Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading.
Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone density compared to normal mice. In order to further… Expand
Utilizing Regulatory T Cells Against Rheumatoid Arthritis
Regulatory T (Treg) cells are essential for normal immune surveillance systems, and their dysfunction leads to development of diseases, such as autoimmune disorders. CD4+CD25+ Treg cells are… Expand
c-Myc-Induced Survivin Is Essential for Promoting the Notch-Dependent T Cell Differentiation from Hematopoietic Stem Cells
Notch is indispensable for T cell lineage commitment, and is needed for thymocyte differentiation at early phases. During early stages of T cell development, active Notch prevents other lineage… Expand
Early childhood caries among Hutterite preschool children in Manitoba, Canada.
INTRODUCTION This study investigated the prevalence of early childhood caries (ECC) among Hutterite preschool children from different colonies in southwestern Manitoba, Canada. METHODS Following… Expand
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity
Pluripotent stem cells (PSCs) have the potential to produce almost all of the cells in the body, including regulatory T cells (Tregs). However, the exact conditions required for the development of… Expand
Hepatitis B Virus Immunopathology, Model Systems, and Current Therapies
- P. Sandhu, M. Haque, Tessa Humphries-Bickley, S. Ravi, J. Song
- Medicine, Biology
- Front. Immunol.
- 13 April 2017
Most people develop acute hepatitis B virus (HBV)-related hepatitis that is controlled by both humoral and cellular immune responses following acute infection. However, a number of individuals in… Expand
Regulation of A1 by OX40 Contributes to CD8+ T Cell Survival and Anti-Tumor Activity
The TNFR family member OX40 (CD134) is critical for optimal clonal expansion and survival of T cells. However, the intracellular targets of OX40 in CD8 T cells are not fully understood. Here we show… Expand
MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene.
- R. Al-Sadi, M. Youssef, +5 authors T. Ma
- Medicine, Biology
- American journal of physiology. Gastrointestinal…
- 1 February 2019
Matrix metalloproteinase-9 (MMP-9) has been implicated as being an important pathogenic factor in inflammatory bowel disease (IBD). MMP-9 is markedly elevated in intestinal tissue of patients with… Expand
Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells
ABSTRACT Optimal approaches to differentiate tumor antigen-specific cytotoxic T lymphocytes (CTLs) from pluripotent stem cells (PSCs) remain elusive. In the current study, we showed that combination… Expand
Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes.
The autoantigen-specific Tregs from pluripotent stem cells (PSCs), i.e., PSC-Tregs, have the ability to suppress autoimmunity. PSC-Tregs can be programmed to be tissue associated and to infiltrate… Expand