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Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage. Expand
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Results indicate that telomerase is essential for telomere length maintenance but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice. Expand
Anti-proliferative activity of silver nanoparticles
The results suggest that cancer cells are susceptible to damage with lack of recovery from Ag-np-induced stress, and signalling cascades are believed to play key roles in cytoskeleton deformations and ultimately to inhibit cell proliferation. Expand
Ku acts in a unique way at the mammalian telomere to prevent end joining.
It is proposed that Ku localizes to internal regions of the telomere via a high-affinity interaction with TRF1, and acts in a unique way at theTelomere to prevent end joining. Expand
Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression
A critical role is demonstrated for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression and a similar susceptibility to spontaneous chromosomal damage and a profound and equivalent predisposition to lymphomas and other cancers. Expand
Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation
Two-step phosphorylation of Chk1 at S317 and S345 appeared to be required for proper localization of ChK1 to centrosomes, suggesting the distinct effects of these phosphorylations. Expand
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
It is shown that Ku70, Ku80, and DNA-PKcs, with which Ku interacts, associate in vivo with telomeric DNA in several human cell types, and it is demonstrated that these associations are not significantly affected by DNA-damaging agents. Expand
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
Mammalian telomerase is essential for the maintenance of telomere length [1-5]. Its catalytic core comprises a reverse transcriptase component (TERT) and an RNA component. While the biochemical roleExpand
hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells.
It is shown that hTERT overexpression not only reduces the basal cellular reactive oxygen species (ROS) levels but also inhibits endogenous ROS production in response to stimuli that induce intracellular ROS generation, and in doing so endowing cancer cells with the ability to evade death stimuli. Expand
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
It is demonstrated that multiple and distinct human cancer precursor lesions, but not corresponding malignant cancers, are comprised of cells that display hallmarks of TDIS, and it is shown that telomeric repeats indeed are hypersensitive to DNA replication stress. Expand