Share This Author
Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
- P. Asharani, Grace Low Kah Mun, M. Hande, S. Valiyaveettil
- Biology, ChemistryACS Nano
- 24 February 2009
A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Anti-proliferative activity of silver nanoparticles
The results suggest that cancer cells are susceptible to damage with lack of recovery from Ag-np-induced stress, and signalling cascades are believed to play key roles in cytoskeleton deformations and ultimately to inhibit cell proliferation.
Ku acts in a unique way at the mammalian telomere to prevent end joining.
It is proposed that Ku localizes to internal regions of the telomere via a high-affinity interaction with TRF1, and acts in a unique way at theTelomere to prevent end joining.
Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression
A critical role is demonstrated for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression and a similar susceptibility to spontaneous chromosomal damage and a profound and equivalent predisposition to lymphomas and other cancers.
Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation
- H. Niida, Y. Katsuno, Birendranath Banerjee, M. Hande, M. Nakanishi
- BiologyMolecular and Cellular Biology
- 22 January 2007
Two-step phosphorylation of Chk1 at S317 and S345 appeared to be required for proper localization of ChK1 to centrosomes, suggesting the distinct effects of these phosphorylations.
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
It is demonstrated that multiple and distinct human cancer precursor lesions, but not corresponding malignant cancers, are comprised of cells that display hallmarks of TDIS, and it is shown that telomeric repeats indeed are hypersensitive to DNA replication stress.
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells.
It is shown that hTERT overexpression not only reduces the basal cellular reactive oxygen species (ROS) levels but also inhibits endogenous ROS production in response to stimuli that induce intracellular ROS generation, and in doing so endowing cancer cells with the ability to evade death stimuli.