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Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer.
Photodynamic therapy is emerging as a viable modality for the treatment of many cancers. A limiting factor in its use against intracavity tumors such as disseminated ovarian cancer is insufficientExpand
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On the mechanism of the tumour-localising effect in photodynamic therapy.
  • M. Hamblin, E. Newman
  • Chemistry, Medicine
  • Journal of photochemistry and photobiology. B…
  • 1 April 1994
The proposed mechanisms by which tumours concentrate photosensitisers are reviewed. Tumour-associated macrophages have been shown by others to accumulate up to nine times the level of porphyrins asExpand
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Photosensitizer targeting in photodynamic therapy. I. Conjugates of haematoporphyrin with albumin and transferrin.
  • M. Hamblin, E. Newman
  • Chemistry, Medicine
  • Journal of photochemistry and photobiology. B…
  • 1 October 1994
Conjugates of haematoporphyrin (HP) with serum albumin and transferrin were prepared, purified by gel filtration and characterized by high performance liquid chromatography (HPLC), polyacrylamide gelExpand
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Photosensitizer targeting in photodynamic therapy. II. Conjugates of haematoporphyrin with serum lipoproteins.
  • M. Hamblin, E. Newman
  • Chemistry, Medicine
  • Journal of photochemistry and photobiology. B…
  • 1 November 1994
Conjugates between haematoporphyrin (HP) and human low-density lipoprotein (LDL), human high-density lipoprotein (HDL) and bovine HDL have been prepared, purified and characterized. HP-LDL isExpand
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Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells.
A marked effect of charge modification on the uptake and phototoxicity of a photoimmunoconjugate (PIC) was demonstrated. A site-specific conjugation strategy was developed to attach theExpand
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Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer.
The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated. Chlorin(e6)c(e6) was attached site specifically toExpand
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A green fluorescent protein-expressing murine tumour but not its wild-type counterpart is cured by photodynamic therapy
The ideal cancer treatment should both destroy the primary tumour and at the same time educate the immune system to recognise the tumour as foreign so that distant metastases will also be eradicated.Expand
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Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer
Optimizing photodynamic therapy involves attempting to increase both the absolute tumour content of photosensitizer and the selectivity between tumour and surrounding normal tissue. One reason whyExpand
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Pegylation of charged polymer-photosensitiser conjugates: effects on photodynamic efficacy
Conjugates between photosensitisers (PS) and charged polymeric carriers are under investigation for photodynamic therapy of cancer and may allow targeting to certain cell types or compartments inExpand
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The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review.
In recent years there have been an increasing number of in vitro and in vivo studies that show positive results regarding antimicrobial photodynamic therapy (aPDT) used in dentistry. These includeExpand
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