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Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages
TLDR
It is demonstrated that activation of Toll‐like receptor (TLR)‐4 results in PI 3‐kinase‐MyD88 complex formation, and that PI 3-kinase activity selectively leads to cytokine induction downstream of TLR4. Expand
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.
TLDR
Pulmonary effluent neutrophils, macrophages, and elastase activity were increased by day 3 of life in infants with respiratory distress syndrome eventually developing bronchopulmonary dysplasia, and Elastase inhibitory capacity and alpha 1-proteinase inhibitor activity were reduced in infants developing chronic lung disease. Expand
Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol.
TLDR
In respiratory failure, the lipid-protein complexes from lung lavage were not surface active, whereas that from healthy controls had surface properties similar to lung surfactant, and phospholipids from patients with respiratory failure were similar to those from respiratory distress syndrome in the newborn. Expand
Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth.
TLDR
IL-1 in amniotic fluid in preterm labor may promote lung maturation and thus be part of a host-defense mechanism that prepares the fetus for extrauterine life. Expand
The Use of Synthetic Peptides in the Formation of Biophysically and Biologically Active Pulmonary Surfactants
TLDR
The data demonstrate that several peptides matching the carboxy-terminal sequence of the SP-B protein, when appropriately recombined with the phospholipids dipalmitoylphosphatidycholine and phosphatidylglycerol, are capable of producing a synthetic surfactant with biophysical and biologic activity approaching that of human Surfactant derived from amniotic fluid. Expand
Maternal Endotoxin-Induced Preterm Birth in Mice: Fetal Responses in Toll-Like Receptors, Collectins, and Cytokines
TLDR
It is proposed that maternal LPS response leads to PTB and acute decrease of immune proteins in epithelial lining of fetal lung, rather than with proinflammatory activation, which has been previously observed in intraamniotic inflammation. Expand
Glycolipid accumulation in bronchoalveolar space in adult respiratory distress syndrome.
TLDR
The glycolipid composition of cell-free bronchoalveolar lavage from healthy subjects and from adult patients with respiratory distress syndrome is studied to consider their potential role in the pathogenesis of adult respiratory distress Syndrome. Expand
Surfactant in respiratory distress syndrome and lung injury.
TLDR
A future challenge is to understand how to inhibit or redirect the inflammatory response from tissue destruction and poor growth towards normal lung development and regeneration. Expand
Surfactant protein A, phosphatidylcholine, and surfactant inhibitors in epithelial lining fluid. Correlation with surface activity, severity of respiratory distress syndrome, and outcome in small
TLDR
Of the infants weighing less than 1,000 g, those who were going to die or develop bronchopulmonary dysplasia had a strikingly lower SP-A/SPC ratio during the first week than those surviving without BPD. Expand
Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs.
TLDR
A single fetal exposure to endotoxin resulted in large improvements in postnatal lung function and increases in surfactant concentrations after preterm delivery, qualitatively larger than those achieved with betamethasone. Expand
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