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Conductin/axin2 and Wnt signalling regulates centrosome cohesion
Activated Wnt/β‐catenin signalling is a characteristic of many cancers and drives cell‐cycle progression. Here, we report a mechanism linking Wnt/β‐catenin signalling to centrosome separation. WeExpand
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Cell cycle control of Wnt/β‐catenin signalling by conductin/axin2 through CDC20
Wnt/β‐catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapidExpand
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Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
Chromosomal instability (CIN), a hallmark of most colon tumors, may promote tumor progression by increasing the rate of genetic aberrations. CIN is thought to arise as a consequence of improperExpand
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Wnt Signaling Inhibits Forkhead Box O3a-induced Transcription and Apoptosis through Up-regulation of Serum- and Glucocorticoid-inducible Kinase 1*
In human cancers, mutations in components of the Wnt signaling pathway lead to β-catenin stabilization and result in augmented gene transcription. HCT116 colon cancer cells carry stabilizingExpand
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CIN by WNT: Growth Pathways, Mitotic Control and Chromosomal Instability in Cancer
There is mounting evidence suggesting that an instable genome is directly involved in the development of cancer. The predominant form of genomic instability in most cancers presents itself as anExpand
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Amer1/WTX couples Wnt‐induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
Phosphorylation of the Wnt receptor low‐density lipoprotein receptor‐related protein 6 (LRP6) by glycogen synthase kinase 3β (GSK3β) and casein kinase 1γ (CK1γ) is a key step in Wnt/β‐cateninExpand
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Restricted expression of mouse GCMa/Gcm1 in kidney and thymus
Mouse Glial Cells Missing a (mGCMa) belongs to a small family of transcription factors named after the prototypical GCM from Drosophila. mGCMa was expected to regulate gliogenesis, but instead foundExpand
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Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling
ABSTRACT Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/&bgr;-catenin signalling that promote degradation of &bgr;-catenin. Whereas axin is constitutivelyExpand
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Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling.
The link of chromatin remodeling to both neurodevelopment and cancer has recently been highlighted by the identification of mutations affecting BAF chromatin-remodeling components, such as ARID1B, inExpand
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Amer2 Protein Interacts with EB1 Protein and Adenomatous Polyposis Coli (APC) and Controls Microtubule Stability and Cell Migration*
Background: Amer2 localizes to the plasma membrane, interacts with adenomatous polyposis coli, and regulates Wnt signaling. Results: Amer2 recruits the microtubule-associated protein EB1 to theExpand
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