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Are PFCAs bioaccumulative? A critical review and comparison with regulatory criteria and persistent lipophilic compounds.
TLDR
The bioaccumulation potential of perfluorinated acids with seven fluorinated carbons or less appears to be several orders of magnitude lower than "legacy" persistent lipophilic compounds classified as bioaccuulative. Expand
Modeling global-scale fate and transport of perfluorooctanoate emitted from direct sources.
TLDR
The model results suggest that concentrations in Arctic biota may continue to rise long after direct emissions have been substantially reduced or eliminated, since water is the primary exposure medium for ArcticBiota. Expand
Renal elimination of perfluorocarboxylates (PFCAs).
TLDR
A basolateral membrane efflux pathway for the reabsorption of PFCAs in the kidney is discussed in this review, which could provide a future research direction toward a better understanding of the mechanisms of P FCA renal elimination. Expand
Polyfluorinated chemicals in a spatially and temporally integrated food web in the Western Arctic.
TLDR
It is concluded that differing pharmacokinetics complicate the use of branched to linear ratios of PFCAs in attributing their presence to a specific manufacturing process. Expand
Investigation of the biodegradation potential of a fluoroacrylate polymer product in aerobic soils.
TLDR
The biodegradation of fluoroacrylate polymer and residuals is calculated to contribute less than 5 tonnes of PFO per year globally to PFCAs present in the environment. Expand
Partitioning and removal of perfluorooctanoate during rain events: the importance of physical-chemical properties.
TLDR
It is shown that PFOA exists primarily in the particle phase in ambient air near direct sources of emissions and is efficiently scavenged by rain droplets, making wet deposition an important removal mechanism for emissions originating as either PFO a or APFO. Expand
High-resolution atmospheric modeling of fluorotelomer alcohols and perfluorocarboxylic acids in the North American troposphere.
TLDR
Emission calculations and modeling results indicate that atmospheric inputs of PFCAs in North America from fluorotelomer-based products will decline by an order of magnitude in the near future as a result of current industry commitments to reduce manufacturing emissions and lower the residual fluorOTelomer alcohol raw material and trace PFCA product content. Expand
Calculation of chemical elimination half-life from blood with an ongoing exposure source: the example of perfluorooctanoic acid (PFOA).
TLDR
This work provides a review of the first-order equations that have been developed to calculate intrinsic and apparent half-life values and the potential bias that can result from confusing these two values. Expand
Elimination kinetics of perfluorohexanoic acid in humans and comparison with mouse, rat and monkey.
TLDR
The consistent weight-normalized elimination half-lives for PFHxA in mammalian species indicates that results obtained from animal models are suitable for establishment of PFHXA benchmark dose and reference dose hazard endpoints for use in human risk assessments. Expand
Inhalation and oral toxicokinetics of 6:2 FTOH and its metabolites in mammals.
TLDR
Current environmental air concentrations of 6:2 FTOH are estimated to result in plasma concentrations of PFHxA, PFHpA and 5:3 Acid that are less than or equal to typical LOQ values, in agreement with extant biomonitoring results. Expand
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