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An amphipathic alpha-helical decapeptide in phosphatidylcholine is an effective synthetic lung surfactant.
TLDR
The data demonstrate that a small water-soluble synthetic peptide containing an amphipathic alpha-helical structure combined solely with the major lipid of natural lung surfactant is effective in restoring lung compliance and gas exchange in surfactants-deficient lungs and may be useful in treatment of the respiratory distress syndromes.
Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin.
TLDR
The development of MDL 28,050 and other effective antithrombin agents are outlined through the description of the structure-activity relationships (SAR) for these peptides, which are effective in a variety of in vitro and in vivo models of thrombosis.
Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides.
TLDR
Three series of synthetic peptides were synthesized to study the effects of sulfation in hirudin-derived peptides and replaced all the Glu residues with (O-sulfato)Ser yielded an analogue with full antithrombin potency.
An Amphipathic a-Helical Decapeptide Phosphatidylcholine Is an Effedive Synthetic Lung Surfactant •
TLDR
The data demonstrate that a small water-soluble synthetic peptide containing an amphipathic a-helical struc­ ture combined solely with the major lipid of natural lung surfactant is effective in restoring lung compliance and gas exchange in surfactants-deficient lungs and may be useful in treatment of the respiratory distress syndromes.