M. H. Payne

Publications9
h-index6
Citations134
Highly Influential Citations2
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An amphipathic alpha-helical decapeptide in phosphatidylcholine is an effective synthetic lung surfactant.
TLDR
The data demonstrate that a small water-soluble synthetic peptide containing an amphipathic alpha-helical structure combined solely with the major lipid of natural lung surfactant is effective in restoring lung compliance and gas exchange in surfactants-deficient lungs and may be useful in treatment of the respiratory distress syndromes.
Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin.
TLDR
The development of MDL 28,050 and other effective antithrombin agents are outlined through the description of the structure-activity relationships (SAR) for these peptides, which are effective in a variety of in vitro and in vivo models of thrombosis.
C-terminal modifications of neuropeptide Y and its analogs leading to selectivity for the mouse brain receptor over the porcine spleen receptor
Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine.
Separation of anticoagulant peptide MDL 28,050 from its deletion by-products by capillary zone electrophoresis
Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides.
TLDR
Three series of synthetic peptides were synthesized to study the effects of sulfation in hirudin-derived peptides and replaced all the Glu residues with (O-sulfato)Ser yielded an analogue with full antithrombin potency.
C-terminal peptide alcohol, acid and amide analogs of desulfato hirudin54-65 as antithrombin agents.
An Amphipathic a-Helical Decapeptide Phosphatidylcholine Is an Effedive Synthetic Lung Surfactant •
TLDR
The data demonstrate that a small water-soluble synthetic peptide containing an amphipathic a-helical struc­ ture combined solely with the major lipid of natural lung surfactant is effective in restoring lung compliance and gas exchange in surfactants-deficient lungs and may be useful in treatment of the respiratory distress syndromes.
Surfactant pulmonaire synthetique ayant des proprietes antioxydantes