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An amphipathic alpha-helical decapeptide in phosphatidylcholine is an effective synthetic lung surfactant.
- L. McLean, J. Lewis, M. H. Payne
- Chemistry, BiologyThe American review of respiratory disease
- 1 February 1993
The data demonstrate that a small water-soluble synthetic peptide containing an amphipathic alpha-helical structure combined solely with the major lipid of natural lung surfactant is effective in restoring lung compliance and gas exchange in surfactants-deficient lungs and may be useful in treatment of the respiratory distress syndromes.
Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin.
- J. Krstenansky, R. Broersma, T. J. Owen, M. H. Payne, M. T. Yates, S. Mao
- Biology, ChemistryThrombosis and haemostasis
- 12 April 1990
The development of MDL 28,050 and other effective antithrombin agents are outlined through the description of the structure-activity relationships (SAR) for these peptides, which are effective in a variety of in vitro and in vivo models of thrombosis.
C-terminal modifications of neuropeptide Y and its analogs leading to selectivity for the mouse brain receptor over the porcine spleen receptor
Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine.
Separation of anticoagulant peptide MDL 28,050 from its deletion by-products by capillary zone electrophoresis
Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides.
- M. H. Payne, J. Krstenansky, M. T. Yates, S. Mao
- Biology, ChemistryJournal of medicinal chemistry
- 1 March 1991
Three series of synthetic peptides were synthesized to study the effects of sulfation in hirudin-derived peptides and replaced all the Glu residues with (O-sulfato)Ser yielded an analogue with full antithrombin potency.
C-terminal peptide alcohol, acid and amide analogs of desulfato hirudin54-65 as antithrombin agents.
An Amphipathic a-Helical Decapeptide Phosphatidylcholine Is an Effedive Synthetic Lung Surfactant •
The data demonstrate that a small water-soluble synthetic peptide containing an amphipathic a-helical struc ture combined solely with the major lipid of natural lung surfactant is effective in restoring lung compliance and gas exchange in surfactants-deficient lungs and may be useful in treatment of the respiratory distress syndromes.
Surfactant pulmonaire synthetique ayant des proprietes antioxydantes