• Publications
  • Influence
LOCALIZATION OF ANTIGEN IN TISSUE CELLS
TLDR
Improvements in a method for the specific microscopic localization of antigen in tissue cells are described and two isomeric series derived from nitrofluorescein are described.
LOCALIZATION OF ANTIGEN IN TISSUE CELLS
TLDR
It was found that each of the three proteins was present in the nuclei of each cell type enumerated above, often in higher concentration than in the cytoplasm, which employs the serological specificity of the protein as a natural "marker".
LOCALIZATION OF ANTIGEN IN TISSUE CELLS III. CELLULAR DISTRIBUTION OF PNEUMOCOCCAL POLYSACCHARIDES TYPES II AND III IN THE MOUSE
TLDR
The cytological distribution of the pneumococcal polysaccharides, types II and III, was followed in the tissues of the mouse, and the significance of its fixation in relation to its antigenicity and possible toxicity in mice is discussed.
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE.
  • M. H. Kaplan
  • Biology, Medicine
    Journal of immunology
  • 1 April 1963
TLDR
The immunologic relationship between streptococcal cell wall antigen and myofibers and smooth muscle of vessel walls is consistent with the hypothesis that bound γ-globulin observed in rheumatic hearts in these sites is derived from immune bodies.
PRESENCE OF BOUND IMMUNOGLOBULINS AND COMPLEMENT IN THE MYOCARDIUM IN ACUTE RHEUMATIC FEVER. ASSOCIATION WITH CARDIAC FAILURE.
TLDR
Evidence that the Group A streptococcus possesses antigens immunologically related to human heart tissue and that such crossreactive autoantibodies are associated with both the poststreptococcal state and rheumatic heart disease is supported.
Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reactive protein in rabbits. Association with necrosis in local inflammatory lesions.
TLDR
Findings are consistent with the hypothesis that CxRP is formed locally at the site of inflammation from tissue elements undergoing necrotic change, and secondary deposition from the blood at the inflammatory site cannot be excluded, but is considered less likely in view of the failure to obtain evidence of a cellular localization of Cx RP in other organs.
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC
TLDR
Sera from patients with recent streptococcal infection or non-suppurative sequelae exhibit with variable frequency a precipitin reaction in agar gel with a partially purified strePTococcal antigen, providing evidence that induction of cross-reactive autoantibody to heart in certain individuals is associated with streptitiscal infection.
Immunologic studies of heart tissue. IV. Serologic reactions with human heart tissue as revealed by immunofluorescent methods: isoimmune, Wassermann, and autoimmune reactions.
TLDR
Serologic reactions with homologous or autologous heart were observed particularly frequently with sera from rheumatic patients approximately 2 weeks following cardiac surgery, as well as in some non-rheumatic Patients following cardiac or thoracic surgery or acute myocardial infarction.
...
1
2
3
4
5
...