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Identification of Harman as the Antibiotic Compound Produced by a Tunicate-Associated Bacterium
The alkaloid harman, previously reported from some marine invertebrates, was identified as the antibiotic substance of the tunicate-associated bacterium Enterococcus faecium. It exhibitedExpand
Metabolites from the Sponge-Associated Bacterium Pseudomonas Species
Abstract: Quinolones and a phosphatidyl glyceride were isolated from the sponge-associated bacterial strain Pseudomonas sp. Structures were elucidated by spectroscopic analysis and chemicalExpand
Grossularine-1 and grossularine-2, cytotoxic α-carbolines from the tunicate: Dendrodoa grossularia
Abstract Several indole derivatives were isolated from the tunicate: Dendrodoa grossularia among which two α-carbolines: grossularine-1 (revised structure) and grossularine-2. The structures wereExpand
Purification and Partial Identification of Novel Antimicrobial Protein from Marine Bacterium Pseudoalteromonas Species Strain X153
The X153 bacterium protected bivalve larvae against mortality, following experimental challenges with ichthyopathogenic Vibrio, and may be useful in aquaculture as a probiotic bacterium. Expand
Biologically active quinone and hydroquinone sesquiterpenoids from the sponge smenospongia sp.
Abstract This work describes isolation, structure and biological activity of quinone- and hydroquinone sesquiterpenoids biosynthesized by a sponge Snenospongia sp. Structures were established byExpand
Physicochemical characterization and dissolution of norfloxacin/cyclodextrin inclusion compounds and PEG solid dispersions
Abstract Increase in the poor water solubility and dissolution rate of norfloxacin was studied. Two systems were used: solid dispersion with PEG 6000 prepared using the fusion method and inclusionExpand
Nifedipine loaded-polymeric microspheres: preparation and physical characteristics
Abstract Nifedipine-loaded microspheres of cellulosic polymers were prepared by a solvent evaporation method. The goal of this work was to investigate the influence of some process parameters on theExpand
New bromoditerpenes from the red alga Sphaerococcus coronopifolius.
Two new bromoditerpenes have been isolated from S. coronopifolius and were responsible for the antimalarial activity of the extract, against the chloroquine resistant Plasmodium falsciparum FCB1 strains with an IC(50) of 1 microM. Expand
Design and in vitro evaluation of adhesive matrix for transdermal delivery of propranolol.
  • M. Guyot, F. Fawaz
  • Medicine, Chemistry
  • International journal of pharmaceutics
  • 20 June 2000
It is demonstrated that propranolol was essentially dissolved in the HPMC matrix and dispersed in the two other matrix types, and the kinetic of drug release from most matrix types was more closely described by the square-root model (Higuchi). Expand