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The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
- S. Grétarsdóttir, G. Thorleifsson, +29 authors Jeffrey R Gulcher
- Biology, Medicine
- Nature Genetics
- 1 October 2003
We previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped this locus and tested it for association with stroke. We found the strongest association in the gene encoding… Expand
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial.
CONTEXT Myocardial infarction (MI) is the leading cause of death in the world. Variants in the 5-lipoxygenase-activating protein (FLAP) gene are associated with risk of MI. OBJECTIVE To determine… Expand
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug delivery vectors due to their biological origin and inherent intercellular biomolecule delivery capability.… Expand
The 2016 revised World Health Organization definition of ‘myelodysplastic syndrome with isolated del(5q)’; prognostic implications of single versus double cytogenetic abnormalities
The definition of the myelodysplastic syndrome (MDS) subtype ‘MDS with isolated del(5q)’ was expanded to include cases with one additional non‐chromosome 7 based cytogenetic abnormality in the 2016… Expand
Corrigendum: The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
Nat. Genet. 35, 131–138 (2003). In Supplementary Table 2 online, SNP 41 was incorrectly labeled as rs152312. The correct label is rs12153798.
Gas and Bloating-Controlling Emissions: A Case-Based Review for the Primary Care Provider.
The evaluation of the patient with gas and bloating can be complex and the treatment extremely challenging. In this article, a simplified approach to the history and relevant physical examination is… Expand
Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma.
Communication between diseased cells and the microenvironment is a complex yet crucial element in progression of varied pathological processes. Recent studies in cancer highlight an important role… Expand
Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.
- V. Sandanayaka, B. Mamat, +7 authors Jasbir Singh
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 May 2010
Novel piperidine and piperazine derivatives have been designed and tested as inhibitors of LTA(4) hydrolase (LTA(4)H). Most potent compounds showed good potency in both enzymatic and functional human… Expand