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Calcium bursts induced by nanosecond electric pulses.
We report here real-time imaging of calcium bursts in human lymphocytes exposed to nanosecond, megavolt-per-meter pulsed electric fields. Ultra-short (less than 30 ns), high-field (greater than 1Expand
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Nanoelectropulse-induced phosphatidylserine translocation.
Nanosecond, megavolt-per-meter, pulsed electric fields induce phosphatidylserine (PS) externalization, intracellular calcium redistribution, and apoptosis in Jurkat T-lymphoblasts, without causingExpand
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Nanoelectropulse-driven membrane perturbation and small molecule permeabilization
BackgroundNanosecond, megavolt-per-meter pulsed electric fields scramble membrane phospholipids, release intracellular calcium, and induce apoptosis. Flow cytometric and fluorescence microscopyExpand
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Ultrashort pulsed electric fields induce membrane phospholipid translocation and caspase activation: differential sensitivities of Jurkat T lymphoblasts and rat glioma C6 cells
Megavolt-per-meter electric pulses with durations shorter than charging time constants associated with external cell membrane dielectric properties can generate significant voltages on the membranesExpand
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pH-sensitive Photoluminescence of CdSe/ZnSe/ZnS Quantum Dots in Human Ovarian Cancer Cells.
The photoluminescence of mercaptoacetic acid (MAA)-capped CdSe/ZnSe/ZnS semiconductor nanocrystal quantum dots (QDs) in SKOV-3 human ovarian cancer cells is pH-dependent, suggesting applications inExpand
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Nanosecond electric pulse-induced calcium entry into chromaffin cells.
Electrically excitable bovine adrenal chromaffin cells were exposed to nanosecond duration electric pulses at field intensities ranging from 2 MV/m to 8 MV/m and intracellular calcium levelsExpand
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Pulse generators for pulsed electric field exposure of biological cells and tissues
This paper describes three pulse generators: a spark gap switched coaxial cable, a spark gap switched Blumlein, and a solid state modulator, developed for applying ultrashort electrical pulses toExpand
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Modern Pulsed Power: Charlie Martin and Beyond
In this introduction to the Special Issue on pulsed power and its applications, background information is provided for the nonspecialist to better understand the many challenges in designing pulsED power systems, and the wide diversity of applications that are now emerging. Expand
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Nanopore formation and phosphatidylserine externalization in a phospholipid bilayer at high transmembrane potential.
Atomic-resolution molecular dynamics simulations of lipid bilayers containing 7% phosphatidylserine (PS) on one leaflet are consistent with experimental observations of membrane poration and PSExpand
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Nanopore-facilitated, voltage-driven phosphatidylserine translocation in lipid bilayers--in cells and in silico.
Nanosecond, megavolt-per-meter pulses--higher power but lower total energy than the electroporative pulses used to introduce normally excluded material into biological cells--produce largeExpand
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