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Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.
- M. Guix, A. Faber, +8 authors J. Engelman
- Chemistry, Medicine
- The Journal of clinical investigation
- 1 July 2008
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We investigated mechanisms of acquired resistance to the EGFR TKI gefitinib by… Expand
Transforming Growth Factor β Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab
ABSTRACT In HER2-overexpressing mammary epithelial cells, transforming growth factor β (TGF-β) activated phosphatidylinositol-3 kinase (PI3K)/Akt and enhanced survival and migration. Treatment with… Expand
Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers.
- M. Guix, N. M. Granja, +15 authors C. Arteaga
- Journal of clinical oncology : official journal…
- 20 February 2008
PURPOSE To administer the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib to patients with operable untreated breast cancer during the immediate preoperative period and to… Expand
Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.
Knockdown of the tumor suppressor phosphatase Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) with shRNA in three estrogen receptor (ER)-positive breast cancer cell lines resulted in… Expand
Elastofibroma Dorsi as a Cause of Shoulder Pain or Snapping Scapula
- J. Majó, I. Gracia, A. Doncel, M. Valera, A. Nunez, M. Guix
- Clinical orthopaedics and related research
- 1 July 2001
Elastofibroma dorsi is a benign soft tissue tumor, not well-known because of its low incidence, located in the chest wall in the subscapular area. In 10 patients with elastofibroma dorsi, the… Expand
Osteoid and bone formation in desmoplastic malignant melanoma
A 77‐year‐old man presented a recurrent subungual malignant melanoma with desmoplastic features in which heterotopic bone had developed. Histological, histochemical and immunohistochemical findings… Expand
[Synthetic absorbable PDS explant for the treatment of retinal detachment].
The following article discusses the experimental and clinical reasons for using absorbable synthetic explants in retinal surgery. We have carried out experimental studies with absorbable synthetic… Expand
Measuring intraepithelial lymphocytes, surface area, and volume of lamina propria in the jejunal mucosa of coeliac patients.
An accurate morphometric method is described for quantifying the intraepithelial lymphocytes (IEL), the area of the epithelium, and the volume of the lamina propria in jejunal mucosa of coeliac… Expand
Prostacyclin and thromboxane production by autogenous femoral veins grafted into the arterial circulation of the dog.
- C. de Castellarnau, C. Cullaré, +4 authors M. Rutllant
- Thrombosis and haemostasis
- 25 April 1989
Vascular prostacyclin (PGI2) production is different in the arteries and veins of the dog. Experiments were performed to determine whether chronic grafting of the femoral vein into the arterial… Expand
Hepatoid gastric adenocarcinoma.
A case of hepatoid gastric adenocarcinoma is reported. The tumor had the histological and immunohistochemical features of both liver cell carcinoma and conventional intestinal-type adenocarcinoma. We… Expand