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Sodium-channel defects in benign familial neonatal-infantile seizures

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Comparison of polarization properties of human adult microglia and blood‐derived macrophages

This work compares phenotypic and functional properties of microglia derived from the adult human CNS with macrophages derived from peripheral blood monocytes in response to M1 and M2 polarizing conditions to delineate distinctive properties ofmicroglia compared with exogenous myeloid cells in response with signals derived from an inflammatory environment in the CNS.
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Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Different TIME subtypes were defined to stratify TNBCs, predict outcomes, and identify potential therapeutic targets for TNBC, with implications for current therapies including immune checkpoint blockade.
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Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

A conserved neural tri-lineage cancer hierarchy centered around glial progenitor-like cells is found, and this hierarchal map can be used to identify therapeutic targets specific to progenitors cancer stem cells.
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Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

The results indicate that the interpretation of 18F-THK5351 PET images, with respect to tau, is confounded by the high MAO-B availability across the entire brain.
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Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.

This work, the first study of gene expression profiles in pGBM, provides valuable insight into active pathways and targets in a cancer with minimal survival, and suggests that these tumors cannot be understood exclusively through studies of aGBM.
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Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma

This work analyzed the failure pattern in 20 consecutive patients with complete resection of the gadolinium-enhancing portion of GBM demonstrated on the immediate post-operative magnetic resonance study, and who underwent a radical course of radiotherapy and chemotherapy.
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Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis.

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Intraoperative brain cancer detection with Raman spectroscopy in humans

A handheld Raman spectroscopy probe enabled detection of invasive brain cancer intraoperatively in patients with grade 2 to 4 gliomas and may be able to classify cell populations in real time, making it an ideal guide for surgical resection and decision-making.
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The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps

The enhanced virulence of the overexpression strain of A. nidulans was associated with increased resistance to NADPH oxidase-dependent neutrophil extracellular traps in vitro, and was not observed in neutropenic mice or mice deficient in NADPH-oxidase that are unable to form NETs.
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