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Comparison of polarization properties of human adult microglia and blood‐derived macrophages
Both microglia, the resident myeloid cells of the CNS parenchyma, and infiltrating blood‐derived macrophages participate in inflammatory responses in the CNS. Macrophages can be polarized into M1 andExpand
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Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.
PURPOSE Pediatric glioblastoma (pGBM) is a rare, but devastating brain tumor. In contrast to GBM in adults (aGBM), little is known about the mechanisms underlying its development. Our aim is to gainExpand
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Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain
Background18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351 retention in brain regions thought to containExpand
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Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis.
PURPOSE Despite multimodality treatments, the outcome of patients with glioblastoma multiforme remains poor. In an attempt to improve results, we have begun a program of accelerated hypofractionatedExpand
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Intraoperative brain cancer detection with Raman spectroscopy in humans
A handheld Raman spectroscopy probe enabled detection of invasive brain cancer intraoperatively in patients with grade 2 to 4 gliomas. Probing for brain tumors Gliomas are invasive cancers, spreadingExpand
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Lipomatous, vascular, and chondromatous benign tumors of the peripheral nerves: representative cases and review of the literature.
Benign peripheral nerve lesions of lipomatous, vascular, and chondromatous origin are very rare. Only one previous case of brachial plexus involvement by such a tumor has been reported. The authorsExpand
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Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth
Glioblastoma (GBM) is the most common and deadly malignant brain cancer, with a median survival of less than two years. GBM displays a cellular complexity that includes brain tumour-initiating cellsExpand
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Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma
Glioblastomas (GBM) are highly motile cancers that invade through normal brain. In the absence of curative chemotherapy this invasion, beyond surgical and radiotherapy margins, to distant brain sitesExpand
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Treatment of granulomatous amoebic encephalitis with voriconazole and miltefosine in an immunocompetent soldier.
A 38-year-old male immunocompetent soldier developed generalized seizures. He underwent surgical debulking and a progressive demyelinating pseudotumor was identified. Serology and molecular testingExpand
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Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians.
BACKGROUND Caspase recruitment domain-containing protein 9 (CARD9) deficiency is an autosomal recessive primary immunodeficiency conferring human susceptibility to invasive fungal disease, includingExpand
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