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Antibodies to Poly(I) · poly(C)
Sera of rabbits immunized with poly(I) · poly(C) adsorbed to methylated serum albumin react with poly(I) · poly(C), poly(I) and poly(C). Three families of antibodies have been isolated by affinity… Expand
Reactivity of antibodies to guanosine modified by the carcinogen N-acetoxy-N-2-acetylaminofluorene.
The geometry of the regions of DNA substituted by AAF residues is the same in native and denatured DNA, and the affinity of the antibodies is smaller for DNA-AAF than for Guo-AAF. Expand
Selenium bioavailability as selenite (74Se) and as a selenium drug (76Se) by stable isotope methodology.
- V. Ducros, A. Favier, M. Guigues
- Chemistry, Medicine
- Journal of trace elements and electrolytes in…
- 1 September 1991
No significant difference in the metabolism of selenium was observed between "Granions de Sélénium" and selenite, and both compounds present two maximal absorption peaks at 6 h and 12 h and a bioavailability of 76%. Expand
Further studies on the interaction between polynucleotides and antibodies to poly(inosinic acid). poly(cytidylic acid).
It is concluded that all the nucleotide residues covered by the Fab fragment binding site do not interact with the amino acid residues, and circular dichroism studies of the complexes between Fab fragments and polynucleotides are in favor of some conformational change of the polyn nucleotides. Expand
Recognition of chemically damaged DNA by the gene 32 protein from bacteriophage T4.
The binding of gene 32 protein from bacteriophage T4 to DNA which has been chemically modified with carcinogens or antitumor drugs is investigated and the possible role of single‐strand binding proteins in DNA repair mechanisms is discussed. Expand
Recognition of polynucleotides by antibodies to poly(I), poly(C).
The comparison of the association constants leads to the conclusion that several atoms of the base residues do not interact with the amino acid residues of the binding site of Fab fragment while the hydroxyl groups of furanose rings interact. Expand
[Lithium modifications of the cataleptogenic properties of various neuroleptic drugs in the rat].
- S. Dessaigne, A. Scotto, M. Guigues
- Biology, Medicine
- Comptes rendus des seances de la Societe de…
After unique ip injection (11,78 mEq/kg) LiCl increases in the Rat catalepsy produced by chlorpromazine, prochlorperazine, fluphenazine, levomepromazine, haloperidol and reserpine. This phenomenon is… Expand
[Determination of pilocarpine and isopilocarpine by high performance liquid chromatography in normal phase. The stability of eye drops with a pilocarpine base and comparison of this method with a…
Specific recognition by the tripeptide lysyl-tryptophyl-alpha-lysine of structural damage induced in DNA by platinum derivatives.
- T. Le Doan, M. Guigues, J. Toulmé, C. Hélène
- Chemistry, Medicine
- Biochimica et biophysica acta
- 21 August 1985
A comparison of fluorescence quenching data for native and modified DNAs demonstrates that modification by dienPt has no effect on stacking interactions and that high levels of modifications by trans Pt are required to observe a change in stacking efficiency, and modification by cis Pt induces the formation of strong stacking sites. Expand