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The histamine H4 receptor is functionally expressed on T(H)2 cells.
BACKGROUND Histamine influences T-cell reactions via histamine receptors 1 and 2. The histamine receptor 4 (H(4)R) is the most recently identified histamine receptor and is also expressed on humanExpand
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Histamine H1, H3 and H4 receptors are involved in pruritus
Histamine has long been recognised as a classical inducer of pruritus. However, the specific mechanism of histamine-induced itch has still not been fully understood. The H1 and H4 receptor appear toExpand
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Histamine down‐regulates IL‐27 production in antigen‐presenting cells
Histamine is a potent mediator in allergic inflammation with immunomodulatory properties. Since histamine was described to inhibit IL‐12 production in human APCs, we hypothesized that also theExpand
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Microcirculation in chronic venous insufficiency
In this review, the anatomy and physiology of the venous system and its pathophysiology are described. Theories regarding the possible causes of disturbances in venous microangiopathy are summarized.Expand
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Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function
To cite this article: Gschwandtner M, Rossbach K, Dijkstra D, Bäumer W, Kietzmann M, Stark H, Werfel T, Gutzmer R. Murine and human Langerhans cells express a functional histamine H4 receptor:Expand
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Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor.
BACKGROUND Epidermal hyperproliferation resulting in acanthosis is an important clinical observation in patients with atopic dermatitis, and its underlying mechanisms are not completely understood.Expand
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Histamine H4 receptor activation on human slan‐dendritic cells down‐regulates their pro‐inflammatory capacity
6‐Sulpho LacNAc dendritic cells (slanDC) are a major population of human blood DC that are highly pro‐inflammatory, as characterized by their outstanding capacity to produce tumour necrosis factor‐αExpand
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Human memory Th17 cells express a functional histamine H4 receptor.
The histamine H4 receptor is functionally expressed on CD4(+) T cells and in particular on human CD4(+) Th2-polarized T cells. Interleukin (IL)-17-producing T cells (Th17 cells) represent a newlyExpand
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Histamine Downregulates the Th1-Associated Chemokine IP-10 in Monocytes and Myeloid Dendritic Cells
Background: Histamine is an important mediator of allergic diseases. It modulates the cytokine expression of various subtypes of antigen-presenting cells by four known receptors,Expand
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Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells
The function of skin mast cells has been well documented in IgE‐mediated allergic reactions, whereas other mast cell functions are poorly defined. This study aimed at identifying novel mast cellExpand
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