• Publications
  • Influence
Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle.
Our purpose here is to test the hypothesis that Randall's plaques, calcium phosphate deposits in kidneys of patients with calcium renal stones, arise in unique anatomical regions of the kidney, theirExpand
  • 477
  • 37
  • PDF
Porous calcium polyphosphate scaffolds for bone substitute applications -- in vitro characterization.
Porous structures were formed by gravity sintering calcium polyphosphate (CPP) particles of either 106-150 or 150-250 microm size to form samples with 30-45 vol% porosity with pore sizes in the rangeExpand
  • 328
  • 14
Long-term intermittent compressive stimulation improves the composition and mechanical properties of tissue-engineered cartilage.
Tissue engineering of articular cartilage is a promising alternative for cartilage repair. However, it has been difficult to develop tissue in vitro that mimicks native cartilage. CartilaginousExpand
  • 156
  • 10
Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model.
There has been interest in developing novel biological treatments to repair focal cartilage defects. We have developed a method of forming biphasic constructs ("osteochondral"-type plug) in vitroExpand
  • 185
  • 9
Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis
Macrophages are activated in inflammation and during early phases of repair processes. Interestingly, they are also present in bone during development, but their function during this process isExpand
  • 130
  • 9
Effects of low doses of strontium on bone quality and quantity in rats.
Strontium (Sr) has been shown to increase bone mass when given at low doses. In this study, the diets of rats containing 0.50% calcium were supplemented with Sr (0.19 and 0.40% of SrCl2 orally) forExpand
  • 160
  • 8
Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice
The cellular and molecular mechanisms that underlie age-dependent osteoporosis, the most common disease in the Western Hemisphere, are poorly understood in part due to the lack of appropriate animalExpand
  • 224
  • 7
Identifying the Relative Contributions of Rac1 and Rac2 to Osteoclastogenesis
Rac small GTPases may play an important regulatory role in osteoclastogenesis. Our in vitro and in vivo results show that both Rac1 and Rac2 are required for optimal osteoclast differentiation, butExpand
  • 117
  • 7
Long‐term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro
The formation of cartilaginous tissue in vitro is a promising alternative to repair damaged articular cartilage. However, recent attempts to tissue‐engineer articular cartilage that has similarExpand
  • 176
  • 6
Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation.
Overcoming the limited ability of articular cartilage to self-repair may be possible through tissue engineering. However, bioengineered cartilage formed using current methods does not match theExpand
  • 131
  • 6