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In vivo staging of regional amyloid deposition
TLDR
The highly consistent regional hierarchy of PET-evidenced amyloids deposition across participants resembles neuropathologic observations and suggests a predictable regional sequence that may be used to stage an individual's progress of amyloid pathology in vivo. Expand
Convergent Findings of Altered Functional and Structural Brain Connectivity in Individuals with High Functioning Autism: A Multimodal MRI Study
TLDR
The results indicate common sites of structural and functional alterations in higher order association cortex areas and may provide multimodal imaging support to the long-standing hypothesis of autism as a disorder of impaired higher-order multisensory integration. Expand
Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer’s disease dementia
TLDR
Dementia with Lewy bodies may be characterized by a more selective degeneration of the cholinergic BF compared to AD, which may be related to the differential cognitive profiles in both conditions. Expand
Multimodal analysis of functional and structural disconnection in Alzheimer's disease using multiple kernel SVM
TLDR
Combined multimodal imaging data did not significantly improve classification accuracy compared to the best single measures alone and the support vector machine (SVM) algorithm ran the SVM algorithm and validated the results using leave‐one‐out cross‐validation. Expand
Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease
TLDR
The findings indicate that cholinergic degeneration in AD occurs against a background of age-related atrophy and that exacerbated atrophy in AD can be detected at earliest stages of cognitive impairment. Expand
The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
TLDR
The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Expand
Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol
TLDR
This work aims to produce a set of HarP labels for the proper training and certification of tracers and algorithms. Expand
In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson’s disease
TLDR
It is demonstrated that the future cognitive status of newly diagnosed patients can be predicted from the volume of the nucleus basalis of Meynert, with implications for the development of interventions for cognitive decline in Parkinson’s disease dementia. Expand
Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection
TLDR
The potential clinical usefulness of single or multimodal imaging markers is being investigated in selected patient samples from clinical expert centres, but additional research is needed before these promising imaging markers can be successfully translated from research into clinical practice in routine care. Expand
Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease.
TLDR
MRI-based measures of regional gray matter volume and associated multivariate analysis techniques of regional interactions of gray matter densities provide insight into the onset and temporal dynamics of cortical atrophy as a close proxy for regional neuronal loss and a basis of functional impairment in specific neuronal networks. Expand
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