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Biallelic Inactivation of BRCA2 in Fanconi Anemia
TLDR
It is shown that cell lines derived from FA-B and FA-D1 patients have biallelic mutations in BRCA2 and express truncated BRC a2 proteins, which may result in cancer risks similar to those observed in families withBRCA1 or BRCa2 mutations. Expand
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
TLDR
Findings indicate that previous observations concerning Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem Cells in a tissue with a low rate of spontaneous proliferation. Expand
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
TLDR
This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation, and is described as an X-linked gene with a novel expression pattern. Expand
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
TLDR
It is reported that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Expand
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
TLDR
The data indicate that the monoubiquitination of FANCD2 is highly regulated, and they suggest that FANcd2/BRCA1 complexes and FAN CD2/RAD51 complexes participate in an S-phase-specific cellular process, such as DNA repair by homologous recombination. Expand
Cell fusion is the principal source of bone-marrow-derived hepatocytes
TLDR
It is concluded that hepatocytes derived form bone marrow arise from cell fusion and not by differentiation of haematopoietic stem cells. Expand
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
TLDR
This system provides a robust platform to produce high-quality human hepatocytes for tissue culture and may be useful for testing the toxicity of drug metabolites and for evaluating pathogens dependent on human liver cells for replication. Expand
The Fanconi anaemia/BRCA pathway
TLDR
Fanconi anaemia is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents, and the FA proteins could be involved in the cell-cycle checkpoint and DNA-repair pathways. Expand
The origin and liver repopulating capacity of murine oval cells
TLDR
It is concluded that hepatic oval cells do not originate in bone marrow but in the liver itself, and that they have valuable properties for therapeutic liver repopulation. Expand
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
TLDR
This study indicates that CRISPR-Cas9–mediated genome editing is possible in adult animals and has potential for correction of human genetic diseases. Expand
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