Biallelic Inactivation of BRCA2 in Fanconi Anemia
- N. Howlett, T. Taniguchi, A. D’Andrea
- Biology, MedicineScience
- 13 June 2002
It is shown that cell lines derived from FA-B and FA-D1 patients have biallelic mutations in BRCA2 and express truncated BRC a2 proteins, which may result in cancer risks similar to those observed in families withBRCA1 or BRCa2 mutations.
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
- Carolyn J. Brown, A. Ballabio, H. Willard
- BiologyNature
- 3 January 1991
This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation, and is described as an X-linked gene with a novel expression pattern.
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
- Meritxell Huch, C. Dorrell, H. Clevers
- BiologyNature
- 14 February 2013
Findings indicate that previous observations concerning Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem Cells in a tissue with a low rate of spontaneous proliferation.
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
- E. Lagasse, Heather Connors, M. Grompe
- Biology, MedicineNature Network Boston
- 1 November 2000
It is reported that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver.
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
- T. Taniguchi, I. Garcı́a-Higuera, P. Andreassen, R. Gregory, M. Grompe, A. D’Andrea
- BiologyBlood
- 1 October 2002
The data indicate that the monoubiquitination of FANCD2 is highly regulated, and they suggest that FANcd2/BRCA1 complexes and FAN CD2/RAD51 complexes participate in an S-phase-specific cellular process, such as DNA repair by homologous recombination.
Cell fusion is the principal source of bone-marrow-derived hepatocytes
- Xin Wang, H. Willenbring, M. Grompe
- Biology, MedicineNature
- 24 April 2003
It is concluded that hepatocytes derived form bone marrow arise from cell fusion and not by differentiation of haematopoietic stem cells.
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
This system provides a robust platform to produce high-quality human hepatocytes for tissue culture and may be useful for testing the toxicity of drug metabolites and for evaluating pathogens dependent on human liver cells for replication.
The Fanconi anaemia/BRCA pathway
- A. D’Andrea, M. Grompe
- Biology, MedicineNature Reviews. Cancer
- 2003
Fanconi anaemia is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents, and the FA proteins could be involved in the cell-cycle checkpoint and DNA-repair pathways.
The origin and liver repopulating capacity of murine oval cells
- Xin Wang, M. Foster, M. Al‐Dhalimy, E. Lagasse, M. Finegold, M. Grompe
- Biology, MedicineProceedings of the National Academy of Sciences…
- 30 September 2003
It is concluded that hepatic oval cells do not originate in bone marrow but in the liver itself, and that they have valuable properties for therapeutic liver repopulation.
The ploidy-conveyor of mature hepatocytes as a source of genetic variation
- A. Duncan, Matthew H Taylor, M. Grompe
- BiologyNature
- 2 September 2010
It is shown that multipolar mitotic spindles form frequently in mouse polyploid hepatocytes and can result in one-step ploidy reversal to generate offspring with halved chromosome content, a phenomenon that the authors term the ‘ploidy conveyor’.
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