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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
The immunoproteasome, a distinct class of proteasome found predominantly in monocytes and lymphocytes, is known to shape the antigenic repertoire presented on class I major histocompatibility… Expand
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.
Dendritic cells (DCs) are potent antigen-presenting cells that are able to initiate and modulate immune responses and are hence exploited as cellular vaccines for immunotherapy. Their capacity to… Expand
Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
Constitutive proteasomes and immunoproteasomes shape the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules by harboring different sets of catalytically active… Expand
Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on major histocompatibility class I molecules to CD8+ T cells and thereby induce protective immunity against… Expand
CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2.
The control of dendritic cell (DC) migration is pivotal for the initiation of cellular immune responses. When activated with inflammatory stimuli, the chemokine receptor CCR7 is up-regulated on DCs.… Expand
A third interferon-gamma-induced subunit exchange in the 20S proteasome.
- M. Groettrup, R. Kraft, S. Kostka, S. Standera, R. Stohwasser, P. Kloetzel
- Medicine, Biology
- European journal of immunology
- 1 April 1996
The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex… Expand
Immunoproteasomes Largely Replace Constitutive Proteasomes During an Antiviral and Antibacterial Immune Response in the Liver1
- S. Khan, M. van den Broek, K. Schwarz, R. de Giuli, P. A. Diener, M. Groettrup
- Biology, Medicine
- The Journal of Immunology
- 15 December 2001
The proteasome is critically involved in the production of MHC class I-restricted T cell epitopes. Proteasome activity and epitope production are altered by IFN-γ treatment, which leads to a gradual… Expand
An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.
- P. André, M. Groettrup, +7 authors V. Lotteau
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 27 October 1998
Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease inhibitory drugs exerted effects in… Expand
A role for the proteasome regulator PA28α in antigen presentation
CYTOTOXIC T cells recognize viral proteins as peptide fragments which are produced in the cytosol and transported on major histocompatibility complex (MHC) class I proteins to the cell surface1.… Expand
Proteasomes in immune cells: more than peptide producers?
When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for… Expand