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The diarylquinoline TMC207 for multidrug-resistant tuberculosis.
TLDR
The clinical activity of TMC207 validates ATP synthase as a viable target for the treatment of tuberculosis. Expand
Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
TLDR
The addition of bedaquiline to a preferred background regimen for 24 weeks resulted in faster culture conversion and significantly more culture conversions at 120 weeks, as compared with placebo. Expand
Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance
TLDR
Bedaquiline may contribute to the management of multidrug-resistant tuberculosis by effecting more rapid sputum culture negativity and by preventing acquired resistance to companion drugs. Expand
Import and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae by international travellers (COMBAT study): a prospective, multicentre cohort study.
TLDR
Investigation of the acquisition of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) during international travel, with a focus on predictive factors for acquisition, duration of colonisation, and probability of onward transmission found it to be substantial and worrisome. Expand
Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria
Cally Roper and colleagues analyze the distribution of sulfadoxine resistance mutations and flanking microsatellite loci to trace the emergence and dispersal of drug-resistant Plasmodium falciparumExpand
Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe.
TLDR
RVSV-ZEBOV was reactogenic but immunogenic after a single dose and warrants further evaluation for safety and efficacy, and glycoprotein-binding antibody titers were sustained through 180 days in all participants. Expand
High recombination rate in natural populations of Plasmodium falciparum.
TLDR
Results are consistent with the effective recombination rate expected in natural populations of P. falciparum, predicted on the basis of the underlying molecular rate of meiotic crossover and the coefficient of inbreeding caused by self-fertilization events. Expand
Malaria incidence in Limpopo Province, South Africa, 1998–2007
TLDR
Information from this study may serve as baseline data to determine the course and distribution of malaria in Limpopo province over time, and address the need for better data over a range of epidemic-prone settings. Expand
Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.
TLDR
This review highlights unanswered questions, challenges, recent advances, unresolved operational and technical issues, needs, and opportunities related to tuberculosis diagnostics. Expand
Assessing the Consequences of Stigma for Tuberculosis Patients in Urban Zambia
TLDR
The findings illustrate that many TB patients faced stigma-related issues, often hindering effective TB control and suggesting that current efforts to reduce stigma are not yet optimal. Expand
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